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A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds

The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying‐driven curling of apple peels, hydrogel‐based micro‐scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of rand...

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Detalles Bibliográficos
Autores principales: Zhang, Liucheng, Xiang, Yi, Zhang, Hongbo, Cheng, Liying, Mao, Xiyuan, An, Ning, Zhang, Lu, Zhou, Jinxiong, Deng, Lianfu, Zhang, Yuguang, Sun, Xiaoming, Santos, Hélder A., Cui, Wenguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201264/
https://www.ncbi.nlm.nih.gov/pubmed/32382485
http://dx.doi.org/10.1002/advs.201903553
Descripción
Sumario:The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying‐driven curling of apple peels, hydrogel‐based micro‐scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y‐branches, anastomosis rings, and triangle loops. Adjustable diameters can be achieved by altering the concentration and cross‐linking time of the hydrogel. Based on this rationale, biomimetic microvessels with diameters of 50–500 µm are cultivated in vitro by coculture of MHTs and human umbilical vein endothelial cells. In vivo studies show their excellent performance to promote microcirculation and improve the survival of random skin flaps. In conclusion, the present work proposes and validifies a biomimetic 3D self‐forming method for the fabrication of biomimetic vessels and microvascular scaffolds with high biocompatibility and stability based on hydrogel materials, such as gelatin and hyaluronic acid.