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Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer

Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non-luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of the AR and its regulatory pathway in non-luminal subtypes of br...

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Autores principales: Sa-Nguanraksa, Doonyapat, Pongthong, Wanee, Samarnthai, Norasate, Mitpakdi, Kwanlada, Chuangsuwanich, Tuenjai, Limjindaporn, Thawornchai, Kulprom, Anchalee, O-Charoenrat, Pornchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201307/
https://www.ncbi.nlm.nih.gov/pubmed/32382417
http://dx.doi.org/10.3892/mco.2020.2029
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author Sa-Nguanraksa, Doonyapat
Pongthong, Wanee
Samarnthai, Norasate
Mitpakdi, Kwanlada
Chuangsuwanich, Tuenjai
Limjindaporn, Thawornchai
Kulprom, Anchalee
O-Charoenrat, Pornchai
author_facet Sa-Nguanraksa, Doonyapat
Pongthong, Wanee
Samarnthai, Norasate
Mitpakdi, Kwanlada
Chuangsuwanich, Tuenjai
Limjindaporn, Thawornchai
Kulprom, Anchalee
O-Charoenrat, Pornchai
author_sort Sa-Nguanraksa, Doonyapat
collection PubMed
description Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non-luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of the AR and its regulatory pathway in non-luminal subtypes of breast cancer. In total, 284 breast cancer patients were recruited from January 2007 to January 2016. Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. Results showed that AR and Lin28 were co-expressed. No association between these proteins and clinicopathological parameters, and survival outcome was found. However, a higher proportion of the patients with AR and Lin28 expression were observed in HER2 subtype. In conclusion, Lin28 may be a novel marker for prognosis and targeted for treatment in HER2 subtype breast cancer.
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spelling pubmed-72013072020-05-07 Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer Sa-Nguanraksa, Doonyapat Pongthong, Wanee Samarnthai, Norasate Mitpakdi, Kwanlada Chuangsuwanich, Tuenjai Limjindaporn, Thawornchai Kulprom, Anchalee O-Charoenrat, Pornchai Mol Clin Oncol Articles Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non-luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of the AR and its regulatory pathway in non-luminal subtypes of breast cancer. In total, 284 breast cancer patients were recruited from January 2007 to January 2016. Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. Results showed that AR and Lin28 were co-expressed. No association between these proteins and clinicopathological parameters, and survival outcome was found. However, a higher proportion of the patients with AR and Lin28 expression were observed in HER2 subtype. In conclusion, Lin28 may be a novel marker for prognosis and targeted for treatment in HER2 subtype breast cancer. D.A. Spandidos 2020-06 2020-04-09 /pmc/articles/PMC7201307/ /pubmed/32382417 http://dx.doi.org/10.3892/mco.2020.2029 Text en Copyright: © Sa-Nguanraksa et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Sa-Nguanraksa, Doonyapat
Pongthong, Wanee
Samarnthai, Norasate
Mitpakdi, Kwanlada
Chuangsuwanich, Tuenjai
Limjindaporn, Thawornchai
Kulprom, Anchalee
O-Charoenrat, Pornchai
Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title_full Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title_fullStr Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title_full_unstemmed Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title_short Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
title_sort expression of androgen receptor and its regulatory molecule lin28 in non-luminal subtype breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201307/
https://www.ncbi.nlm.nih.gov/pubmed/32382417
http://dx.doi.org/10.3892/mco.2020.2029
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