Cargando…

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study

BACKGROUND: North American health authorities recommend 0.4 mg/day folic acid before conception and throughout pregnancy to reduce the risk of neural tube defects. Folic acid is a synthetic form of folate that must be reduced by dihydrofolate reductase and then further metabolized. Recent evidence s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cochrane, Kelsey M., Mayer, Chantal, Devlin, Angela M., Elango, Rajavel, Hutcheon, Jennifer A., Karakochuk, Crystal D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201521/ https://www.ncbi.nlm.nih.gov/pubmed/32370802 http://dx.doi.org/10.1186/s13063-020-04320-3

Ejemplares similares

Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid
por: Cochrane, Kelsey M., et al.
Publicado: (2023)

Association of Plasma Folate, Vitamin B12, and Betaine With Total Homocysteine in Pregnancy, and Effect Modification Due to Folic Acid Versus Natural Folate Supplementation
por: Cochrane, Kelsey, et al.
Publicado: (2022)

Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development
por: Palacios, Ana M., et al.
Publicado: (2022)

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease
por: Williams, Brock A., et al.
Publicado: (2021)

Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells
por: Smith, Desiree, et al.
Publicado: (2017)

Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development
por: Lian, Zenglin, et al.
Publicado: (2022)

Strategies for improving recruitment of pregnant women to clinical research: An evaluation of social media versus traditional offline methods
por: Cochrane, Kelsey M, et al.
Publicado: (2022)

Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts
por: Obeid, Rima, et al.
Publicado: (2020)

Conversion of calcium‐l‐methylfolate and (6S)‐5‐methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents
por: Turck, Dominique, et al.
Publicado: (2022)

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate
por: Vidmar Golja, Maša, et al.
Publicado: (2020)

Synthetic Folic Acid
Publicado: (1946)

Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLC–MS/MS and its application to a pharmacokinetic study()
por: Zheng, Xiao-Hong, et al.
Publicado: (2015)

The Amount of Folic Acid in Weekly Iron-Folic Acid Supplements Should Be Increased From 0.4 to 2,8 mg to Reduce Neural Tube Defects (NTD)
por: Samson, Kaitlyn, et al.
Publicado: (2022)

Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate
por: Ringling, Christiane, et al.
Publicado: (2017)

5-Methyltetrahydrofolate Is a Crucial Factor in Determining the Bioaccessibility of Folate in Bread
por: Liu, Fengyuan, et al.
Publicado: (2022)

Laying hen performance, egg quality improved and yolk 5-methyltetrahydrofolate content increased by dietary supplementation of folic acid
por: Bagheri, Sattar, et al.
Publicado: (2019)

Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women
por: Kubo, Yoshinori, et al.
Publicado: (2020)

Folates, folic acid and preconception care – a review
por: House, Simon H, et al.
Publicado: (2021)

Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid
por: Martiniak, Yvonne, et al.
Publicado: (2014)

Effect of once weekly folic acid supplementation on erythrocyte folate concentrations in women to determine potential to prevent neural tube defects: a randomised controlled dose-finding trial in Malaysia
por: Samson, Kaitlyn L I, et al.
Publicado: (2020)

Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells
Publicado: (1996)

Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
por: Blair, J. A., et al.
Publicado: (1970)

Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial
por: Williams, Brock A., et al.
Publicado: (2020)

Folate during reproduction: the Canadian experience with folic acid fortification
por: Lindzon, Gillian, et al.
Publicado: (2007)

Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes
por: Alnabbat, Khadijah I., et al.
Publicado: (2022)

Folic acid inhibits 5‐methyltetrahydrofolate transport across the blood–cerebrospinal fluid barrier: Clinical biochemical data from two cases
por: Akiyama, Tomoyuki, et al.
Publicado: (2022)

[6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth
por: Pannia, Emanuela, et al.
Publicado: (2020)

Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B(12): a case report
por: Tisman, Glenn, et al.
Publicado: (2011)

Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation
por: Tam, Carolyn, et al.
Publicado: (2012)

Weekly iron–folic acid supplements containing 2.8 mg folic acid are associated with a lower risk of neural tube defects than the current practice of 0.4 mg: a randomised controlled trial in Malaysia
por: Samson, Kaitlyn L I, et al.
Publicado: (2020)

Maternal folic acid supplementation and dietary folate intake and congenital heart defects
por: Mao, Baohong, et al.
Publicado: (2017)

Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival
por: Geijsen, Anne J M R, et al.
Publicado: (2020)

The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection
por: Acosta-Elias, Jesus, et al.
Publicado: (2020)

Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates—new perspectives for folate receptor–targeted radionuclide therapy
por: Guzik, Patrycja, et al.
Publicado: (2020)

Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles
por: Menezo, Yves, et al.
Publicado: (2022)

Tolerable Upper Intake Level for Individual Amino Acids in Humans: A Narrative Review of Recent Clinical Studies
por: Elango, Rajavel
Publicado: (2023)

Folate Catabolites in Spot Urine as Non-Invasive Biomarkers of Folate Status during Habitual Intake and Folic Acid Supplementation
por: Niesser, Mareile, et al.
Publicado: (2013)

High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring
por: Pannia, Emanuela, et al.
Publicado: (2021)

Ordering folate assays is no longer justified for investigation of anemias, in folic acid fortified countries
por: Shojania, A Majid, et al.
Publicado: (2010)

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
por: Henry, Curtis J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sm041l8bg0i0jiorem4r4gs5u9