Cargando…
Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation
ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly regarding primary cutaneous anaplastic large cell l...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201522/ https://www.ncbi.nlm.nih.gov/pubmed/32509362 http://dx.doi.org/10.1155/2020/6309736 |
_version_ | 1783529551168536576 |
---|---|
author | Staderini, Michela Mannelli, Lara Antonioli, Elisabetta Puccini, Benedetta Berti, Valentina Mungai, Francesco Vergoni, Federica Carrai, Valentina Rigacci, Luigi Bosi, Alberto |
author_facet | Staderini, Michela Mannelli, Lara Antonioli, Elisabetta Puccini, Benedetta Berti, Valentina Mungai, Francesco Vergoni, Federica Carrai, Valentina Rigacci, Luigi Bosi, Alberto |
author_sort | Staderini, Michela |
collection | PubMed |
description | ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly regarding primary cutaneous anaplastic large cell lymphoma. We present the case of a 65-year-old man, simultaneously diagnosed with ALK-negative anaplastic large cell lymphoma with extranodal localization in the gastrocnemius muscle (stage 1AE) and IgG lambda multiple myeloma (ISS 2, Durie-Salmon stage 3A). Both diseases required therapeutic intervention due to the high proliferative index of lymphoma and the presence of bone lesions attributable to myeloma. The therapeutic program initially included chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone; CHOEP), radiotherapy on the leg, bortezomib, and then consolidation with autologous hematopoietic stem cell transplantation. Despite being on bortezomib treatment and waiting for transplantation, the patient experienced an early myeloma progression that turned out to be refractory to second-line lenalidomide-based treatment. To our knowledge, this is the first case of concurrent diagnosis of extranodal ALK-negative anaplastic large cell lymphoma of the muscle and multiple myeloma. Simultaneous onset can be challenging for clinicians as both diseases may have an aggressive course requiring multiple treatments with increased risk of toxicity and complicated management. |
format | Online Article Text |
id | pubmed-7201522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72015222020-06-05 Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation Staderini, Michela Mannelli, Lara Antonioli, Elisabetta Puccini, Benedetta Berti, Valentina Mungai, Francesco Vergoni, Federica Carrai, Valentina Rigacci, Luigi Bosi, Alberto Case Rep Hematol Case Report ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly regarding primary cutaneous anaplastic large cell lymphoma. We present the case of a 65-year-old man, simultaneously diagnosed with ALK-negative anaplastic large cell lymphoma with extranodal localization in the gastrocnemius muscle (stage 1AE) and IgG lambda multiple myeloma (ISS 2, Durie-Salmon stage 3A). Both diseases required therapeutic intervention due to the high proliferative index of lymphoma and the presence of bone lesions attributable to myeloma. The therapeutic program initially included chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone; CHOEP), radiotherapy on the leg, bortezomib, and then consolidation with autologous hematopoietic stem cell transplantation. Despite being on bortezomib treatment and waiting for transplantation, the patient experienced an early myeloma progression that turned out to be refractory to second-line lenalidomide-based treatment. To our knowledge, this is the first case of concurrent diagnosis of extranodal ALK-negative anaplastic large cell lymphoma of the muscle and multiple myeloma. Simultaneous onset can be challenging for clinicians as both diseases may have an aggressive course requiring multiple treatments with increased risk of toxicity and complicated management. Hindawi 2020-01-16 /pmc/articles/PMC7201522/ /pubmed/32509362 http://dx.doi.org/10.1155/2020/6309736 Text en Copyright © 2020 Michela Staderini et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Staderini, Michela Mannelli, Lara Antonioli, Elisabetta Puccini, Benedetta Berti, Valentina Mungai, Francesco Vergoni, Federica Carrai, Valentina Rigacci, Luigi Bosi, Alberto Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title | Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title_full | Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title_fullStr | Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title_full_unstemmed | Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title_short | Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation |
title_sort | aggressive disease course of multiple myeloma with concomitant alk-negative anaplastic large cell lymphoma: a case report with an unusual presentation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201522/ https://www.ncbi.nlm.nih.gov/pubmed/32509362 http://dx.doi.org/10.1155/2020/6309736 |
work_keys_str_mv | AT staderinimichela aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT mannellilara aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT antoniolielisabetta aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT puccinibenedetta aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT bertivalentina aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT mungaifrancesco aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT vergonifederica aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT carraivalentina aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT rigacciluigi aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation AT bosialberto aggressivediseasecourseofmultiplemyelomawithconcomitantalknegativeanaplasticlargecelllymphomaacasereportwithanunusualpresentation |