Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced l...

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Detalles Bibliográficos
Autores principales: Baktybayeva, Lyailya, Yu, Valentina, Zazybin, Alexey, Zolotareva, Darya, Dauletbakov, Anuar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201524/
https://www.ncbi.nlm.nih.gov/pubmed/32420370
http://dx.doi.org/10.1155/2020/7636290
Descripción
Sumario:A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.

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