Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced l...

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Autores principales: Baktybayeva, Lyailya, Yu, Valentina, Zazybin, Alexey, Zolotareva, Darya, Dauletbakov, Anuar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201524/
https://www.ncbi.nlm.nih.gov/pubmed/32420370
http://dx.doi.org/10.1155/2020/7636290
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author Baktybayeva, Lyailya
Yu, Valentina
Zazybin, Alexey
Zolotareva, Darya
Dauletbakov, Anuar
author_facet Baktybayeva, Lyailya
Yu, Valentina
Zazybin, Alexey
Zolotareva, Darya
Dauletbakov, Anuar
author_sort Baktybayeva, Lyailya
collection PubMed
description A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.
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spelling pubmed-72015242020-05-15 Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds Baktybayeva, Lyailya Yu, Valentina Zazybin, Alexey Zolotareva, Darya Dauletbakov, Anuar Biomed Res Int Research Article A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil. Hindawi 2020-01-13 /pmc/articles/PMC7201524/ /pubmed/32420370 http://dx.doi.org/10.1155/2020/7636290 Text en Copyright © 2020 Lyailya Baktybayeva et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baktybayeva, Lyailya
Yu, Valentina
Zazybin, Alexey
Zolotareva, Darya
Dauletbakov, Anuar
Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title_full Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title_fullStr Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title_full_unstemmed Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title_short Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
title_sort activation of leukopoiesis in rat blood with trimecaine-based ionic compounds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201524/
https://www.ncbi.nlm.nih.gov/pubmed/32420370
http://dx.doi.org/10.1155/2020/7636290
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