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Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2

MicroRNA (miR)-202-3p has attracted a great deal of attention in the fields of oncology, gynecology, and metabolic disorders. However, its role in cardiovascular diseases remains to be clarified. We previously found that disruption of miR-202-3p mediated regulation of expression of soluble (s)ST2, a...

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Autores principales: Li, Lu, Zhong, Danrong, Xie, Yudan, Yang, Xinlei, Yu, Zuozhong, Zhang, Dangui, Jiang, Xinghua, Wu, Yanqing, Wu, Fangqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201562/
https://www.ncbi.nlm.nih.gov/pubmed/32338289
http://dx.doi.org/10.1042/BSR20200378
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author Li, Lu
Zhong, Danrong
Xie, Yudan
Yang, Xinlei
Yu, Zuozhong
Zhang, Dangui
Jiang, Xinghua
Wu, Yanqing
Wu, Fangqin
author_facet Li, Lu
Zhong, Danrong
Xie, Yudan
Yang, Xinlei
Yu, Zuozhong
Zhang, Dangui
Jiang, Xinghua
Wu, Yanqing
Wu, Fangqin
author_sort Li, Lu
collection PubMed
description MicroRNA (miR)-202-3p has attracted a great deal of attention in the fields of oncology, gynecology, and metabolic disorders. However, its role in cardiovascular diseases remains to be clarified. We previously found that disruption of miR-202-3p mediated regulation of expression of soluble (s)ST2, a decoy receptor for interleukin (IL)-33, promotes essential hypertension (EH). In the present study, we first measured miR-202-3p expression levels in the blood of 182 EH cases and 159 healthy controls using TaqMan assays. miR-202-3p levels were shown to be significantly higher in EH cases than controls (fold change = 3.58, P<0.001). Logistic regression analysis revealed that higher miR-202-3p expression was associated with an increased occurrence of EH (adjusted odds ratio (OR): 1.57; 95% confidence interval (CI), 1.36–1.82; P<0.001). Addition of miR-202-3p to traditional risk factors showed an additive prediction value for EH. Further functional experiments indicated that miR-202-3p could be induced by angiotensin II (Ang II) and inhibited by Ang II-triggered soluble ST2 (sST2) expression in a negative feedback manner. Moreover, blood miR-202-3p levels were negatively correlated with sST2 expression in vivo. Our study shows that blood miR-202-3p levels were significantly associated with the occurrence of EH. These findings indicate that miR-202-3p exerts a protective role against EH by antagonizing the induction of sST2 by Ang II.
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spelling pubmed-72015622020-06-10 Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2 Li, Lu Zhong, Danrong Xie, Yudan Yang, Xinlei Yu, Zuozhong Zhang, Dangui Jiang, Xinghua Wu, Yanqing Wu, Fangqin Biosci Rep Cardiovascular System & Vascular Biology MicroRNA (miR)-202-3p has attracted a great deal of attention in the fields of oncology, gynecology, and metabolic disorders. However, its role in cardiovascular diseases remains to be clarified. We previously found that disruption of miR-202-3p mediated regulation of expression of soluble (s)ST2, a decoy receptor for interleukin (IL)-33, promotes essential hypertension (EH). In the present study, we first measured miR-202-3p expression levels in the blood of 182 EH cases and 159 healthy controls using TaqMan assays. miR-202-3p levels were shown to be significantly higher in EH cases than controls (fold change = 3.58, P<0.001). Logistic regression analysis revealed that higher miR-202-3p expression was associated with an increased occurrence of EH (adjusted odds ratio (OR): 1.57; 95% confidence interval (CI), 1.36–1.82; P<0.001). Addition of miR-202-3p to traditional risk factors showed an additive prediction value for EH. Further functional experiments indicated that miR-202-3p could be induced by angiotensin II (Ang II) and inhibited by Ang II-triggered soluble ST2 (sST2) expression in a negative feedback manner. Moreover, blood miR-202-3p levels were negatively correlated with sST2 expression in vivo. Our study shows that blood miR-202-3p levels were significantly associated with the occurrence of EH. These findings indicate that miR-202-3p exerts a protective role against EH by antagonizing the induction of sST2 by Ang II. Portland Press Ltd. 2020-05-05 /pmc/articles/PMC7201562/ /pubmed/32338289 http://dx.doi.org/10.1042/BSR20200378 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cardiovascular System & Vascular Biology
Li, Lu
Zhong, Danrong
Xie, Yudan
Yang, Xinlei
Yu, Zuozhong
Zhang, Dangui
Jiang, Xinghua
Wu, Yanqing
Wu, Fangqin
Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title_full Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title_fullStr Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title_full_unstemmed Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title_short Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2
title_sort blood microrna 202-3p associates with the risk of essential hypertension by targeting soluble st2
topic Cardiovascular System & Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201562/
https://www.ncbi.nlm.nih.gov/pubmed/32338289
http://dx.doi.org/10.1042/BSR20200378
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