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Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. In view of the proven antioxidant effects of probiotics, we pro...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201593/ https://www.ncbi.nlm.nih.gov/pubmed/32411323 http://dx.doi.org/10.1155/2020/2638703 |
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author | Ton, Alyne Mendonça Marques Campagnaro, Bianca Prandi Alves, Gisela Aleixo Aires, Rafaela Côco, Larissa Zambom Arpini, Clarisse Maximo Guerra e Oliveira, Trícia Campos-Toimil, Manuel Meyrelles, Silvana Santos Pereira, Thiago Melo Costa Vasquez, Elisardo Corral |
author_facet | Ton, Alyne Mendonça Marques Campagnaro, Bianca Prandi Alves, Gisela Aleixo Aires, Rafaela Côco, Larissa Zambom Arpini, Clarisse Maximo Guerra e Oliveira, Trícia Campos-Toimil, Manuel Meyrelles, Silvana Santos Pereira, Thiago Melo Costa Vasquez, Elisardo Corral |
author_sort | Ton, Alyne Mendonça Marques |
collection | PubMed |
description | BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. In view of the proven antioxidant effects of probiotics, we proposed that continuous dietary supplementation with milk fermented with kefir grains might improve cognitive and metabolic and/or cellular disorders in the AD patients. METHODS: This study was designed as an uncontrolled clinical investigation to test the effects of probiotic-fermented milk supplementation (2 mL/kg/daily) for 90 days in AD patients exhibiting cognitive deficit. Cognitive assessment, cytokine expression, systemic oxidative stress levels, and blood cell damage biomarkers were evaluated before (T0) and after (T90) kefir synbiotic supplementation. RESULTS: When the patients were challenged to solve 8 classical tests, the majority exhibit a marked improvement in memory, visual-spatial/abstraction abilities, and executive/language functions. At the end of the treatment, the cytometric analysis showed an absolute/relative decrease in several cytokine markers of inflammation and oxidative stress markers ((·)O(2)(–), H(2)O(2), and ONOO(−), ~30%) accompanied by an increase in NO bioavailability (100%). In agreement with the above findings by using the same technique, we observed in a similar magnitude an improvement of serum protein oxidation, mitochondrial dysfunction, DNA damage/repair, and apoptosis. CONCLUSION: In conclusion, we demonstrated that kefir improves cognitive deficits, which seems to be linked with three important factors of the AD—systemic inflammation, oxidative stress, and blood cell damage—and may be a promising adjuvant therapy against the AD progression. |
format | Online Article Text |
id | pubmed-7201593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72015932020-05-14 Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation Ton, Alyne Mendonça Marques Campagnaro, Bianca Prandi Alves, Gisela Aleixo Aires, Rafaela Côco, Larissa Zambom Arpini, Clarisse Maximo Guerra e Oliveira, Trícia Campos-Toimil, Manuel Meyrelles, Silvana Santos Pereira, Thiago Melo Costa Vasquez, Elisardo Corral Oxid Med Cell Longev Research Article BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. In view of the proven antioxidant effects of probiotics, we proposed that continuous dietary supplementation with milk fermented with kefir grains might improve cognitive and metabolic and/or cellular disorders in the AD patients. METHODS: This study was designed as an uncontrolled clinical investigation to test the effects of probiotic-fermented milk supplementation (2 mL/kg/daily) for 90 days in AD patients exhibiting cognitive deficit. Cognitive assessment, cytokine expression, systemic oxidative stress levels, and blood cell damage biomarkers were evaluated before (T0) and after (T90) kefir synbiotic supplementation. RESULTS: When the patients were challenged to solve 8 classical tests, the majority exhibit a marked improvement in memory, visual-spatial/abstraction abilities, and executive/language functions. At the end of the treatment, the cytometric analysis showed an absolute/relative decrease in several cytokine markers of inflammation and oxidative stress markers ((·)O(2)(–), H(2)O(2), and ONOO(−), ~30%) accompanied by an increase in NO bioavailability (100%). In agreement with the above findings by using the same technique, we observed in a similar magnitude an improvement of serum protein oxidation, mitochondrial dysfunction, DNA damage/repair, and apoptosis. CONCLUSION: In conclusion, we demonstrated that kefir improves cognitive deficits, which seems to be linked with three important factors of the AD—systemic inflammation, oxidative stress, and blood cell damage—and may be a promising adjuvant therapy against the AD progression. Hindawi 2020-01-13 /pmc/articles/PMC7201593/ /pubmed/32411323 http://dx.doi.org/10.1155/2020/2638703 Text en Copyright © 2020 Alyne Mendonça Marques Ton et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ton, Alyne Mendonça Marques Campagnaro, Bianca Prandi Alves, Gisela Aleixo Aires, Rafaela Côco, Larissa Zambom Arpini, Clarisse Maximo Guerra e Oliveira, Trícia Campos-Toimil, Manuel Meyrelles, Silvana Santos Pereira, Thiago Melo Costa Vasquez, Elisardo Corral Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title | Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title_full | Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title_fullStr | Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title_full_unstemmed | Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title_short | Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation |
title_sort | oxidative stress and dementia in alzheimer's patients: effects of synbiotic supplementation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201593/ https://www.ncbi.nlm.nih.gov/pubmed/32411323 http://dx.doi.org/10.1155/2020/2638703 |
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