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Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin α(IIb)β(3) inside-out but not outside-in signals

BACKGROUND: Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic activity. A striking therapeutic target for arterial thrombosis is inhibitio...

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Detalles Bibliográficos
Autores principales:	Hou, Shaw-Min, Hsia, Chih-Wei, Tsai, Cheng-Lin, Hsia, Chih-Hsuan, Jayakumar, Thanasekaran, Velusamy, Marappan, Sheu, Joen-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201758/ https://www.ncbi.nlm.nih.gov/pubmed/32375785 http://dx.doi.org/10.1186/s12929-020-0619-5

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