CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead

Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and ma...

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Detalles Bibliográficos
Autores principales: Zhang, Qingyang, Ping, Jieming, Huang, Zirui, Zhang, Xiaoli, Zhou, Jingyi, Wang, Gangyang, Liu, Shaoyang, Ma, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201836/
https://www.ncbi.nlm.nih.gov/pubmed/32411789
http://dx.doi.org/10.1155/2020/1924379
Descripción
Sumario:Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. This review mainly describes the toxicity of CAR-T cell therapy and the challenges of CAR-T cells in the treatment of solid tumors, and looks forward to future development and opportunities for immunotherapy and reviews major breakthroughs in CAR-T cell therapy.

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