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Pathophysiological and Genetic Aspects of Vascular Calcification

Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic fact...

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Autores principales: Escobar Guzman, Luis Fernando, Escobar Guzman, Cristian Andres, Lopes, Neuza Helena Moreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201852/
https://www.ncbi.nlm.nih.gov/pubmed/32411445
http://dx.doi.org/10.1155/2020/5169069
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author Escobar Guzman, Luis Fernando
Escobar Guzman, Cristian Andres
Lopes, Neuza Helena Moreira
author_facet Escobar Guzman, Luis Fernando
Escobar Guzman, Cristian Andres
Lopes, Neuza Helena Moreira
author_sort Escobar Guzman, Luis Fernando
collection PubMed
description Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in vascular calcification and its genetic influence was performed. Methods. A systematic review was conducted in the Medline and PubMed databases and were searched for studies concerning vascular calcification using the keywords and studies published until 2020/01 in English. Inclusion Criteria. Studies in vitro, animal models, and humans. These include cohort (both retrospective and prospective cohort studies), case-control, cross-sectional, and systematic reviews. Exclusion Criteria. Studies before 2003 of the existing literature.
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spelling pubmed-72018522020-05-14 Pathophysiological and Genetic Aspects of Vascular Calcification Escobar Guzman, Luis Fernando Escobar Guzman, Cristian Andres Lopes, Neuza Helena Moreira Cardiol Res Pract Review Article Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in vascular calcification and its genetic influence was performed. Methods. A systematic review was conducted in the Medline and PubMed databases and were searched for studies concerning vascular calcification using the keywords and studies published until 2020/01 in English. Inclusion Criteria. Studies in vitro, animal models, and humans. These include cohort (both retrospective and prospective cohort studies), case-control, cross-sectional, and systematic reviews. Exclusion Criteria. Studies before 2003 of the existing literature. Hindawi 2020-04-14 /pmc/articles/PMC7201852/ /pubmed/32411445 http://dx.doi.org/10.1155/2020/5169069 Text en Copyright © 2020 Luis Fernando Escobar Guzman et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Escobar Guzman, Luis Fernando
Escobar Guzman, Cristian Andres
Lopes, Neuza Helena Moreira
Pathophysiological and Genetic Aspects of Vascular Calcification
title Pathophysiological and Genetic Aspects of Vascular Calcification
title_full Pathophysiological and Genetic Aspects of Vascular Calcification
title_fullStr Pathophysiological and Genetic Aspects of Vascular Calcification
title_full_unstemmed Pathophysiological and Genetic Aspects of Vascular Calcification
title_short Pathophysiological and Genetic Aspects of Vascular Calcification
title_sort pathophysiological and genetic aspects of vascular calcification
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201852/
https://www.ncbi.nlm.nih.gov/pubmed/32411445
http://dx.doi.org/10.1155/2020/5169069
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