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Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels

Mice lacking functional large-conductance voltage- and Ca(2+)-activated K(+) channels (BK channels) are viable but have motor deficits including ataxia and weakness. The cause of weakness is unknown. In this study, we discovered, in vivo, that skeletal muscle in mice lacking BK channels (BK(−/−)) wa...

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Detalles Bibliográficos
Autores principales: Wang, Xueyong, Burke, Steven R.A., Talmadge, Robert J., Voss, Andrew A., Rich, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201880/
https://www.ncbi.nlm.nih.gov/pubmed/32243496
http://dx.doi.org/10.1085/jgp.201912526