The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site

This study by Tóth et al. has defined that the N-terminal MHR1/2 domain is a conserved ADPR binding site in TRPM2 from ancient cnidarians to vertebrate, and that it is the key ligand binding site for invertebrate TRPM2 channel activation by ADPR, the same as observed in human and zebrafish TRPM2.

Detalles Bibliográficos
Autores principales: Lü, Wei, Du, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201883/
https://www.ncbi.nlm.nih.gov/pubmed/32282890
http://dx.doi.org/10.1085/jgp.201912555
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author Lü, Wei
Du, Juan
author_facet Lü, Wei
Du, Juan
author_sort Lü, Wei
collection PubMed
description This study by Tóth et al. has defined that the N-terminal MHR1/2 domain is a conserved ADPR binding site in TRPM2 from ancient cnidarians to vertebrate, and that it is the key ligand binding site for invertebrate TRPM2 channel activation by ADPR, the same as observed in human and zebrafish TRPM2.
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spelling pubmed-72018832020-11-04 The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site Lü, Wei Du, Juan J Gen Physiol Commentary This study by Tóth et al. has defined that the N-terminal MHR1/2 domain is a conserved ADPR binding site in TRPM2 from ancient cnidarians to vertebrate, and that it is the key ligand binding site for invertebrate TRPM2 channel activation by ADPR, the same as observed in human and zebrafish TRPM2. Rockefeller University Press 2020-04-13 /pmc/articles/PMC7201883/ /pubmed/32282890 http://dx.doi.org/10.1085/jgp.201912555 Text en © 2020 Lü and Du http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Lü, Wei
Du, Juan
The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title_full The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title_fullStr The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title_full_unstemmed The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title_short The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
title_sort n-terminal domain in trpm2 channel is a conserved nucleotide binding site
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201883/
https://www.ncbi.nlm.nih.gov/pubmed/32282890
http://dx.doi.org/10.1085/jgp.201912555
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