Cargando…

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edwards, Sarah C., Sutton, Caroline E., Ladell, Kristin, Grant, Emma J., McLaren, James E., Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L., Lalor, Stephen J., Ribot, Julie C., Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A., Thomas, Paul G., McLoughlin, Rachel M., Mills, Kingston H.G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201916/ https://www.ncbi.nlm.nih.gov/pubmed/32106283 http://dx.doi.org/10.1084/jem.20190834

Ejemplares similares

γδ T Cells and NK Cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity
por: Edwards, Sarah C., et al.
Publicado: (2015)

Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis
por: Guo, Xi-zhi J, et al.
Publicado: (2016)

Human αβ and γδ T Cells in Skin Immunity and Disease
por: Cruz, Michelle S., et al.
Publicado: (2018)

The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development
por: Seeland, Isabel, et al.
Publicado: (2018)

Lymph node γδ and αβ CD8(+) T cells share migratory properties
por: Ugur, Milas, et al.
Publicado: (2018)

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification
por: Wiede, Florian, et al.
Publicado: (2017)

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
por: Terrence, Kathleen, et al.
Publicado: (2000)

γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice
por: Phalke, Swati Popat, et al.
Publicado: (2019)

Association between αβ and γδ T-cell subsets and clinicopathological characteristics in patients with breast cancer
por: Zhang, Meng, et al.
Publicado: (2020)

αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals
por: Aghaallaei, Narges, et al.
Publicado: (2021)

T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis
por: Kreslavsky, Taras, et al.
Publicado: (2008)

Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
por: Garbe, Annette I., et al.
Publicado: (2006)

Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling
por: Kang, Joonsoo, et al.
Publicado: (2001)

T-Cell Subpopulations αβ and γδ in Cord Blood of Very Preterm Infants: the Influence of Intrauterine Infection
por: Serwatowska-Bargieł, Agata, et al.
Publicado: (2013)

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence
por: Ishihara, Mikiya, et al.
Publicado: (2023)

Lymph act, TCR αβ, TCR γδ cells in peripheral blood in children with juvenile idiopathic arthritis
por: Mazur-Zielinska, H
Publicado: (2008)

Radiation-induced DNA damage and repair in human γδ and αβ T-lymphocytes analysed by the alkaline comet assay
por: Lisowska, Halina, et al.
Publicado: (2010)

Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells
por: Ziegler, Hendrik, et al.
Publicado: (2014)

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice
por: Zhang, Xiaoli, et al.
Publicado: (2017)

Immunological Characteristics between αβ T (DC) and γδ T (DC) Cells in the Spleen of Breast Cancer-Induced Mice
por: Silva, Polyana Barbosa, et al.
Publicado: (2021)

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease
por: Mannion, Jenny M., et al.
Publicado: (2022)

Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells
por: McCarthy, Neil E., et al.
Publicado: (2020)

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
por: Wang, Baoping, et al.
Publicado: (1998)

CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis
por: Pinheiro, Melina B., et al.
Publicado: (2012)

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells
por: Fleischer, Lauren C., et al.
Publicado: (2020)

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults
por: Beucke, Nicola, et al.
Publicado: (2021)

Nonsurgical treatment of cystic adventitial disease of the popliteal artery caused by functional popliteal artery entrapment syndrome
por: McGinley, Joseph C.
Publicado: (2015)

The γδ variant of T cell large granular lymphocyte leukemia is very similar to the common αβ type: report of two cases
por: Shaw, Gene R., et al.
Publicado: (2008)

Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8(+) αβ and γδ T Lymphocytes with Different Kinetics
por: Zechmann, Maria, et al.
Publicado: (2013)

Suppressive activity of Vδ2(+) γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
por: Schilbach, Karin, et al.
Publicado: (2020)

αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression
por: Strijker, Josephine G. M., et al.
Publicado: (2021)

The Distinct Contributions of Murine T Cell Receptor (TCR)γδ(+) and TCRαβ(+) T Cells to Different Stages of Chemically Induced Skin Cancer
por: Girardi, Michael, et al.
Publicado: (2003)

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2013)

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
por: Van de Walle, Inge, et al.
Publicado: (2013)

Correction: Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8(+) αβ and γδ T Lymphocytes with Different Kinetics
por: Zechmann, Maria, et al.
Publicado: (2014)

Medical emergency teams: implementation and outcome measurement
por: McGinley, Ann, et al.
Publicado: (2007)

Prospects of siponimod in secondary progressive multiple sclerosis
por: McGinley, Marisa, et al.
Publicado: (2018)

Perceived Cause, Environmental Factors, and Consequences of Falls in Adults with Cerebral Palsy: A Preliminary Mixed Methods Study
por: Morgan, Prue, et al.
Publicado: (2015)

Whodunit? The Contribution of Interleukin (IL)-17/IL-22-Producing γδ T Cells, αβ T Cells, and Innate Lymphoid Cells to the Pathogenesis of Spondyloarthritis
por: Reinhardt, Annika, et al.
Publicado: (2018)

Bordeaux 2018: Wine, Cheese, and γδ T Cells
por: Edelblum, Karen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0cj6v3sa3c8glnl9mjfsj9f8vr