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Trib1 regulates T cell differentiation during chronic infection by restraining the effector program
In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood in the context of exhaustion, but targeting effector programs may provide new strate...
Autores principales: | Rome, Kelly S., Stein, Sarah J., Kurachi, Makoto, Petrovic, Jelena, Schwartz, Gregory W., Mack, Ethan A., Uljon, Sacha, Wu, Winona W., DeHart, Anne G., McClory, Susan E., Xu, Lanwei, Gimotty, Phyllis A., Blacklow, Stephen C., Faryabi, Robert B., Wherry, E. John, Jordan, Martha S., Pear, Warren S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201917/ https://www.ncbi.nlm.nih.gov/pubmed/32150623 http://dx.doi.org/10.1084/jem.20190888 |
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