NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF fate reporter mice, we show that synovial NK cells produce GM-CSF in autoantibody-mediated inflammatory arthritis. Synovial NK ce...

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Detalles Bibliográficos
Autores principales: Louis, Cynthia, Fonseca-Guimaraes, Fernando Souza-, Yang, Yuyan, D’Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J., Babon, Jeffrey J., Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S., Huntington, Nicholas D., Wicks, Ian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201918/
https://www.ncbi.nlm.nih.gov/pubmed/32097462
http://dx.doi.org/10.1084/jem.20191421

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