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Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling
Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201921/ https://www.ncbi.nlm.nih.gov/pubmed/32142585 http://dx.doi.org/10.1084/jem.20192282 |
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author | Shi, Yaoyao Zheng, Wenxin Yang, Kaiting Harris, Katharine G. Ni, Kaiyuan Xue, Lai Lin, Wenbin Chang, Eugene B. Weichselbaum, Ralph R. Fu, Yang-Xin |
author_facet | Shi, Yaoyao Zheng, Wenxin Yang, Kaiting Harris, Katharine G. Ni, Kaiyuan Xue, Lai Lin, Wenbin Chang, Eugene B. Weichselbaum, Ralph R. Fu, Yang-Xin |
author_sort | Shi, Yaoyao |
collection | PubMed |
description | Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor microenvironment. Systemic administration of Bifidobacterium leads to its accumulation within the tumor and converts the nonresponder mice into responders to anti-CD47 immunotherapy in a stimulator of interferon genes (STING)– and interferon-dependent fashion. Local delivery of Bifidobacterium potently stimulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatment. Our study identifies the mechanism by which gut microbiota preferentially colonize in tumor sites and facilitate immunotherapy via STING signaling. |
format | Online Article Text |
id | pubmed-7201921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72019212020-11-04 Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling Shi, Yaoyao Zheng, Wenxin Yang, Kaiting Harris, Katharine G. Ni, Kaiyuan Xue, Lai Lin, Wenbin Chang, Eugene B. Weichselbaum, Ralph R. Fu, Yang-Xin J Exp Med Brief Definitive Report Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor microenvironment. Systemic administration of Bifidobacterium leads to its accumulation within the tumor and converts the nonresponder mice into responders to anti-CD47 immunotherapy in a stimulator of interferon genes (STING)– and interferon-dependent fashion. Local delivery of Bifidobacterium potently stimulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatment. Our study identifies the mechanism by which gut microbiota preferentially colonize in tumor sites and facilitate immunotherapy via STING signaling. Rockefeller University Press 2020-03-06 /pmc/articles/PMC7201921/ /pubmed/32142585 http://dx.doi.org/10.1084/jem.20192282 Text en © 2020 Shi et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Shi, Yaoyao Zheng, Wenxin Yang, Kaiting Harris, Katharine G. Ni, Kaiyuan Xue, Lai Lin, Wenbin Chang, Eugene B. Weichselbaum, Ralph R. Fu, Yang-Xin Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title | Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title_full | Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title_fullStr | Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title_full_unstemmed | Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title_short | Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling |
title_sort | intratumoral accumulation of gut microbiota facilitates cd47-based immunotherapy via sting signaling |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201921/ https://www.ncbi.nlm.nih.gov/pubmed/32142585 http://dx.doi.org/10.1084/jem.20192282 |
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