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USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2

USP22 is a cytoplasmic and nuclear deubiquitinating enzyme, and the functions of cytoplasmic USP22 are unclear. Here, we discovered that cytoplasmic USP22 promoted nuclear translocation of IRF3 by deubiquitianting and stabilizing KPNA2 after viral infection. Viral infection induced USP22-IRF3 associ...

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Detalles Bibliográficos
Autores principales:	Cai, Zeng, Zhang, Meng-Xin, Tang, Zhen, Zhang, Qiang, Ye, Jing, Xiong, Tian-Chen, Zhang, Zhi-Dong, Zhong, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201923/ https://www.ncbi.nlm.nih.gov/pubmed/32130408 http://dx.doi.org/10.1084/jem.20191174

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