Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-r...

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Detalles Bibliográficos
Autores principales: Bogie, Jeroen F.J., Grajchen, Elien, Wouters, Elien, Corrales, Aida Garcia, Dierckx, Tess, Vanherle, Sam, Mailleux, Jo, Gervois, Pascal, Wolfs, Esther, Dehairs, Jonas, Van Broeckhoven, Jana, Bowman, Andrew P., Lambrichts, Ivo, Gustafsson, Jan-Åke, Remaley, Alan T., Mulder, Monique, Swinnen, Johannes V., Haidar, Mansour, Ellis, Shane R., Ntambi, James M., Zelcer, Noam, Hendriks, Jerome J.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201924/
https://www.ncbi.nlm.nih.gov/pubmed/32097464
http://dx.doi.org/10.1084/jem.20191660

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