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Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes

Multidrug resistance-1 (MDR1) acts as a chemotherapeutic drug efflux pump in tumor cells, although its physiological functions remain enigmatic. Using a recently developed MDR1-knockin reporter allele (Abcb1a(AME)), we found that constitutive MDR1 expression among hematopoietic cells was observed in...

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Detalles Bibliográficos
Autores principales:	Chen, Mei Lan, Sun, Amy, Cao, Wei, Eliason, Amber, Mendez, Kayla M., Getzler, Adam J., Tsuda, Shanel, Diao, Huitian, Mukori, Clever, Bruno, Nelson E., Kim, Sang Yong, Pipkin, Matthew E., Koralov, Sergei B., Sundrud, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201929/ https://www.ncbi.nlm.nih.gov/pubmed/32302378 http://dx.doi.org/10.1084/jem.20191388

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