Historical overview of the interleukin-6 family cytokine

Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple...

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Detalles Bibliográficos
Autores principales: Kang, Sujin, Narazaki, Masashi, Metwally, Hozaifa, Kishimoto, Tadamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201933/
https://www.ncbi.nlm.nih.gov/pubmed/32267936
http://dx.doi.org/10.1084/jem.20190347
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author Kang, Sujin
Narazaki, Masashi
Metwally, Hozaifa
Kishimoto, Tadamitsu
author_facet Kang, Sujin
Narazaki, Masashi
Metwally, Hozaifa
Kishimoto, Tadamitsu
author_sort Kang, Sujin
collection PubMed
description Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors, it has become a primary therapeutic target among IL-6 family cytokines. Here, we revisit the discovery of IL-6; discuss insights regarding the roles of this family of cytokines; and highlight recent advances in our understanding of regulation of IL-6 expression.
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spelling pubmed-72019332020-11-04 Historical overview of the interleukin-6 family cytokine Kang, Sujin Narazaki, Masashi Metwally, Hozaifa Kishimoto, Tadamitsu J Exp Med Review Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors, it has become a primary therapeutic target among IL-6 family cytokines. Here, we revisit the discovery of IL-6; discuss insights regarding the roles of this family of cytokines; and highlight recent advances in our understanding of regulation of IL-6 expression. Rockefeller University Press 2020-04-08 /pmc/articles/PMC7201933/ /pubmed/32267936 http://dx.doi.org/10.1084/jem.20190347 Text en © 2020 Kang et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Review
Kang, Sujin
Narazaki, Masashi
Metwally, Hozaifa
Kishimoto, Tadamitsu
Historical overview of the interleukin-6 family cytokine
title Historical overview of the interleukin-6 family cytokine
title_full Historical overview of the interleukin-6 family cytokine
title_fullStr Historical overview of the interleukin-6 family cytokine
title_full_unstemmed Historical overview of the interleukin-6 family cytokine
title_short Historical overview of the interleukin-6 family cytokine
title_sort historical overview of the interleukin-6 family cytokine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201933/
https://www.ncbi.nlm.nih.gov/pubmed/32267936
http://dx.doi.org/10.1084/jem.20190347
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