Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers

BACKGROUND: Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized by a small-size and short half-life. The rapid...

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Detalles Bibliográficos
Autores principales: Loureiro, Liliana R., Feldmann, Anja, Bergmann, Ralf, Koristka, Stefanie, Berndt, Nicole, Máthé, Domokos, Hegedüs, Nikolett, Szigeti, Krisztián, Videira, Paula A., Bachmann, Michael, Arndt, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201957/
https://www.ncbi.nlm.nih.gov/pubmed/32370811
http://dx.doi.org/10.1186/s13046-020-01572-4

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