Cargando…

Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines

N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production. NGLY1 is a deglycosylating protein involved in the degradati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mueller, William F., Jakob, Petra, Sun, Han, Clauder-Münster, Sandra, Ghidelli-Disse, Sonja, Ordonez, Diana, Boesche, Markus, Bantscheff, Marcus, Collier, Paul, Haase, Bettina, Benes, Vladimir, Paulsen, Malte, Sehr, Peter, Lewis, Joe, Drewes, Gerard, Steinmetz, Lars M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2020
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202010/ https://www.ncbi.nlm.nih.gov/pubmed/32265286 http://dx.doi.org/10.1534/g3.119.401031

Ejemplares similares

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome
por: Webster, Lauren A., et al.
Publicado: (2018)

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics
por: Ghidelli-Disse, Sonja, et al.
Publicado: (2014)

A method for assaying peptide: N-glycanase/N-glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide
por: Hirayama, Hiroto, et al.
Publicado: (2021)

Identification and characterization of peptide: N- glycanase from Dictyostelium discoideum
por: Gosain, Anuradha, et al.
Publicado: (2012)

Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1
por: Galeone, Antonio, et al.
Publicado: (2017)

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
por: Moorey, Alice R., et al.
Publicado: (2021)

N-Terminal Deletion of Peptide:N-Glycanase Results in Enhanced Deglycosylation Activity
por: Wang, Shengjun, et al.
Publicado: (2009)

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites
por: Matralis, Alexios N., et al.
Publicado: (2019)

Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
por: Hoeijmakers, Wieteke Anna Maria, et al.
Publicado: (2019)

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
por: Yang, Kun, et al.
Publicado: (2018)

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids
por: Lin, Victor J. T., et al.
Publicado: (2022)

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D
por: Perocchi, Fabiana, et al.
Publicado: (2007)

PNG1, a Yeast Gene Encoding a Highly Conserved Peptide:N-Glycanase
por: Suzuki, Tadashi, et al.
Publicado: (2000)

Comprehensive Analysis of the Structure and Function of Peptide:N-Glycanase 1 and Relationship with Congenital Disorder of Deglycosylation
por: Miao, Xiangguang, et al.
Publicado: (2022)

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
por: Penzo, Maria, et al.
Publicado: (2019)

Alternative polyadenylation diversifies post‐transcriptional regulation by selective RNA–protein interactions
por: Gupta, Ishaan, et al.
Publicado: (2014)

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
por: Crouch, Lucy I., et al.
Publicado: (2020)

N-Glycanase 1 Deficiency Is a Rare Cause of Pediatric Neurodegeneration With Neuronal Inclusions and Liver Steatosis
por: Stuut, Thomas, et al.
Publicado: (2021)

1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis
por: Singh, Vinayak, et al.
Publicado: (2022)

INO80 represses osmostress induced gene expression by resetting promoter proximal nucleosomes
por: Klopf, Eva, et al.
Publicado: (2017)

Discovery and characterization of a novel extremely acidic bacterial N-glycanase with combined advantages of PNGase F and A
por: Wang, Ting, et al.
Publicado: (2014)

Antisense expression increases gene expression variability and locus interdependency
por: Xu, Zhenyu, et al.
Publicado: (2011)

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
por: Crowther, Gregory J., et al.
Publicado: (2016)

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity
por: Tomlin, Frederick M., et al.
Publicado: (2017)

Collaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets
por: Lafuente, Maria Jose, et al.
Publicado: (2014)

Identification of Roles for Peptide: N-Glycanase and Endo-β-N-Acetylglucosaminidase (Engase1p) during Protein N-Glycosylation in Human HepG2 Cells
por: Chantret, Isabelle, et al.
Publicado: (2010)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
por: Zhou, Qianxiang, et al.
Publicado: (2016)

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast
por: Castelnuovo, Manuele, et al.
Publicado: (2014)

Ca(2+) signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG
por: Balestra, Aurélia C., et al.
Publicado: (2021)

Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough
por: Holmes, Rebecca K., et al.
Publicado: (2015)

Fingolimod Leads to Immediate Immunological Changes Within 6 h After First Administration
por: Sehr, Tony, et al.
Publicado: (2020)

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
por: Wyllie, Susan, et al.
Publicado: (2018)

Identification of KasA as the cellular target of an anti-tubercular scaffold
por: Abrahams, Katherine A., et al.
Publicado: (2016)

Burkholderia pseudomallei Sequence Type 562 in China and Australia
por: Chen, Hai, et al.
Publicado: (2015)

Proteomic Analysis of Quercetin-Treated K562 Cells
por: Brisdelli, Fabrizia, et al.
Publicado: (2019)

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis
por: Rege, Mayuri, et al.
Publicado: (2015)

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription
por: Hocquet, Clémence, et al.
Publicado: (2018)

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies
por: Wilson, Colin R., et al.
Publicado: (2017)

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei
por: Urbaniak, Michael D., et al.
Publicado: (2012)

Establishment and molecular characterization of decitabine‐resistant K562 cells
por: Wen, Xiang‐Mei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_36futo1tcvrkvs5tlmdu707aq9