TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution

Recent evidence has linked the lysosomal cholesterol accumulation in Niemann–Pick type C1 with anomalies associated with primary ciliogenesis. Here, we report that perturbed intracellular cholesterol distribution imposed by lysosomal cholesterol accumulation during TMEM135 depletion is closely assoc...

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Detalles Bibliográficos
Autores principales: Maharjan, Yunash, Lee, Joon No, Kwak, Seong Ae, Dutta, Raghbendra Kumar, Park, Channy, Choe, Seong‐Kyu, Park, Raekil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202201/
https://www.ncbi.nlm.nih.gov/pubmed/32157776
http://dx.doi.org/10.15252/embr.201948901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202201/
https://www.ncbi.nlm.nih.gov/pubmed/32157776
http://dx.doi.org/10.15252/embr.201948901

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