Cargando…
TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution
Recent evidence has linked the lysosomal cholesterol accumulation in Niemann–Pick type C1 with anomalies associated with primary ciliogenesis. Here, we report that perturbed intracellular cholesterol distribution imposed by lysosomal cholesterol accumulation during TMEM135 depletion is closely assoc...
Autores principales: | Maharjan, Yunash, Lee, Joon No, Kwak, Seong Ae, Dutta, Raghbendra Kumar, Park, Channy, Choe, Seong‐Kyu, Park, Raekil |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202201/ https://www.ncbi.nlm.nih.gov/pubmed/32157776 http://dx.doi.org/10.15252/embr.201948901 |
Ejemplares similares
-
Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion
por: Maharjan, Yunash, et al.
Publicado: (2022) -
Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting
por: Dutta, Raghbendra Kumar, et al.
Publicado: (2021) -
Catalase-deficient mice induce aging faster through lysosomal dysfunction
por: Dutta, Raghbendra Kumar, et al.
Publicado: (2022) -
Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell
por: Mu, Yizhu, et al.
Publicado: (2021) -
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes
por: Wei, Xiaofan, et al.
Publicado: (2021)