Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

[Image: see text] The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to action—to uncover and develop antiviral interventions. One potential therapeutic approach currently being evaluated in numerous clinical trials is the agent remdesivi...

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Autores principales: Eastman, Richard T., Roth, Jacob S., Brimacombe, Kyle R., Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202249/
https://www.ncbi.nlm.nih.gov/pubmed/32483554
http://dx.doi.org/10.1021/acscentsci.0c00489
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author Eastman, Richard T.
Roth, Jacob S.
Brimacombe, Kyle R.
Simeonov, Anton
Shen, Min
Patnaik, Samarjit
Hall, Matthew D.
author_facet Eastman, Richard T.
Roth, Jacob S.
Brimacombe, Kyle R.
Simeonov, Anton
Shen, Min
Patnaik, Samarjit
Hall, Matthew D.
author_sort Eastman, Richard T.
collection PubMed
description [Image: see text] The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to action—to uncover and develop antiviral interventions. One potential therapeutic approach currently being evaluated in numerous clinical trials is the agent remdesivir, which has endured a long and winding developmental path. Remdesivir is a nucleotide analogue prodrug that perturbs viral replication, originally evaluated in clinical trials to thwart the Ebola outbreak in 2014. Subsequent evaluation by numerous virology laboratories demonstrated the ability of remdesivir to inhibit coronavirus replication, including SARS-CoV-2. Here, we provide an overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness.
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spelling pubmed-72022492020-05-06 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 Eastman, Richard T. Roth, Jacob S. Brimacombe, Kyle R. Simeonov, Anton Shen, Min Patnaik, Samarjit Hall, Matthew D. ACS Cent Sci [Image: see text] The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to action—to uncover and develop antiviral interventions. One potential therapeutic approach currently being evaluated in numerous clinical trials is the agent remdesivir, which has endured a long and winding developmental path. Remdesivir is a nucleotide analogue prodrug that perturbs viral replication, originally evaluated in clinical trials to thwart the Ebola outbreak in 2014. Subsequent evaluation by numerous virology laboratories demonstrated the ability of remdesivir to inhibit coronavirus replication, including SARS-CoV-2. Here, we provide an overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness. American Chemical Society 2020-05-04 2020-05-27 /pmc/articles/PMC7202249/ /pubmed/32483554 http://dx.doi.org/10.1021/acscentsci.0c00489 Text en Copyright © 2020 U.S. Government This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Eastman, Richard T.
Roth, Jacob S.
Brimacombe, Kyle R.
Simeonov, Anton
Shen, Min
Patnaik, Samarjit
Hall, Matthew D.
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title_full Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title_fullStr Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title_full_unstemmed Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title_short Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
title_sort remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202249/
https://www.ncbi.nlm.nih.gov/pubmed/32483554
http://dx.doi.org/10.1021/acscentsci.0c00489
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