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Clinical-based Cell Therapies for Heart Disease—Current and Future State
Patients have an ongoing unmet need for effective therapies that reverse the cellular and functional damage associated with heart damage and disease. The discovery that ~1%–2% of adult cardiomyocytes turn over per year provided the impetus for treatments that stimulate endogenous repair mechanisms t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rambam Health Care Campus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202446/ https://www.ncbi.nlm.nih.gov/pubmed/32374254 http://dx.doi.org/10.5041/RMMJ.10401 |
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author | Turner, Darren Rieger, Angela C. Balkan, Wayne Hare, Joshua M. |
author_facet | Turner, Darren Rieger, Angela C. Balkan, Wayne Hare, Joshua M. |
author_sort | Turner, Darren |
collection | PubMed |
description | Patients have an ongoing unmet need for effective therapies that reverse the cellular and functional damage associated with heart damage and disease. The discovery that ~1%–2% of adult cardiomyocytes turn over per year provided the impetus for treatments that stimulate endogenous repair mechanisms that augment this rate. Preclinical and clinical studies provide evidence that cell-based therapy meets these therapeutic criteria. Recent and ongoing studies are focused on determining which cell type(s) works best for specific patient population(s) and the mechanism(s) by which these cells promote repair. Here we review clinical and preclinical stem cell studies and anticipate future directions of regenerative medicine for heart disease. |
format | Online Article Text |
id | pubmed-7202446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Rambam Health Care Campus |
record_format | MEDLINE/PubMed |
spelling | pubmed-72024462020-05-19 Clinical-based Cell Therapies for Heart Disease—Current and Future State Turner, Darren Rieger, Angela C. Balkan, Wayne Hare, Joshua M. Rambam Maimonides Med J Special Issue on Cardiology in the 21st Century Honoring the Contributions of Professor Rafael Beyar Patients have an ongoing unmet need for effective therapies that reverse the cellular and functional damage associated with heart damage and disease. The discovery that ~1%–2% of adult cardiomyocytes turn over per year provided the impetus for treatments that stimulate endogenous repair mechanisms that augment this rate. Preclinical and clinical studies provide evidence that cell-based therapy meets these therapeutic criteria. Recent and ongoing studies are focused on determining which cell type(s) works best for specific patient population(s) and the mechanism(s) by which these cells promote repair. Here we review clinical and preclinical stem cell studies and anticipate future directions of regenerative medicine for heart disease. Rambam Health Care Campus 2020-04-29 /pmc/articles/PMC7202446/ /pubmed/32374254 http://dx.doi.org/10.5041/RMMJ.10401 Text en Copyright: © 2020 Turner et al. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue on Cardiology in the 21st Century Honoring the Contributions of Professor Rafael Beyar Turner, Darren Rieger, Angela C. Balkan, Wayne Hare, Joshua M. Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title | Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title_full | Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title_fullStr | Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title_full_unstemmed | Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title_short | Clinical-based Cell Therapies for Heart Disease—Current and Future State |
title_sort | clinical-based cell therapies for heart disease—current and future state |
topic | Special Issue on Cardiology in the 21st Century Honoring the Contributions of Professor Rafael Beyar |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202446/ https://www.ncbi.nlm.nih.gov/pubmed/32374254 http://dx.doi.org/10.5041/RMMJ.10401 |
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