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Dynamics of outcome after aneurysmal subarachnoid hemorrhage
In this observational study, we analyzed and described the dynamics of the outcome after aneurysmal subarachnoid hemorrhage (SAH) in a collective of 203 cases. We detected a significant improvement of the mean aggregate modified Rankin Score (mRS) in every time interval from discharge to 6 months an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202490/ https://www.ncbi.nlm.nih.gov/pubmed/32312942 http://dx.doi.org/10.18632/aging.103069 |
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author | Hammer, Alexander Ranaie, Gholamreza Yakubov, Eduard Erbguth, Frank Holtmannspoetter, Markus Steiner, Hans-Herbert Janssen, Hendrik |
author_facet | Hammer, Alexander Ranaie, Gholamreza Yakubov, Eduard Erbguth, Frank Holtmannspoetter, Markus Steiner, Hans-Herbert Janssen, Hendrik |
author_sort | Hammer, Alexander |
collection | PubMed |
description | In this observational study, we analyzed and described the dynamics of the outcome after aneurysmal subarachnoid hemorrhage (SAH) in a collective of 203 cases. We detected a significant improvement of the mean aggregate modified Rankin Score (mRS) in every time interval from discharge to 6 months and up to 1 year. Every forth to fifth patient with potential of recovery (mRS 1-5) at discharge improved by 1 mRS point in the time interval from 6 month to 1 year (22.6%). Patients with mRS 3 at discharge had a remarkable late recovery rate (73.3%, p = 0.000085). Multivariate analysis revealed age ≤ 65 years (odds ratio 4.93; p = 0.0045) and “World Federation of Neurological Surgeons” (WFNS) grades I and II (odds ratio 4.77; p = 0.0077) as significant predictors of early improvement (discharge to 6 months). Absence of a shunting procedure (odds ratio 8.32; p = 0.0049) was a significant predictor of late improvement (6 months to 1 year), but not age ≤ 65 years (p = 0.54) and WFNS grades I and II (p = 0.92). Thus, late recovery (6 month to 1 year) is significant and independent from age and WFNS grade. |
format | Online Article Text |
id | pubmed-7202490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-72024902020-05-11 Dynamics of outcome after aneurysmal subarachnoid hemorrhage Hammer, Alexander Ranaie, Gholamreza Yakubov, Eduard Erbguth, Frank Holtmannspoetter, Markus Steiner, Hans-Herbert Janssen, Hendrik Aging (Albany NY) Research Paper In this observational study, we analyzed and described the dynamics of the outcome after aneurysmal subarachnoid hemorrhage (SAH) in a collective of 203 cases. We detected a significant improvement of the mean aggregate modified Rankin Score (mRS) in every time interval from discharge to 6 months and up to 1 year. Every forth to fifth patient with potential of recovery (mRS 1-5) at discharge improved by 1 mRS point in the time interval from 6 month to 1 year (22.6%). Patients with mRS 3 at discharge had a remarkable late recovery rate (73.3%, p = 0.000085). Multivariate analysis revealed age ≤ 65 years (odds ratio 4.93; p = 0.0045) and “World Federation of Neurological Surgeons” (WFNS) grades I and II (odds ratio 4.77; p = 0.0077) as significant predictors of early improvement (discharge to 6 months). Absence of a shunting procedure (odds ratio 8.32; p = 0.0049) was a significant predictor of late improvement (6 months to 1 year), but not age ≤ 65 years (p = 0.54) and WFNS grades I and II (p = 0.92). Thus, late recovery (6 month to 1 year) is significant and independent from age and WFNS grade. Impact Journals 2020-04-20 /pmc/articles/PMC7202490/ /pubmed/32312942 http://dx.doi.org/10.18632/aging.103069 Text en Copyright © 2020 Hammer et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hammer, Alexander Ranaie, Gholamreza Yakubov, Eduard Erbguth, Frank Holtmannspoetter, Markus Steiner, Hans-Herbert Janssen, Hendrik Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title | Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title_full | Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title_fullStr | Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title_full_unstemmed | Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title_short | Dynamics of outcome after aneurysmal subarachnoid hemorrhage |
title_sort | dynamics of outcome after aneurysmal subarachnoid hemorrhage |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202490/ https://www.ncbi.nlm.nih.gov/pubmed/32312942 http://dx.doi.org/10.18632/aging.103069 |
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