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The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy

Radiotherapy is the major approach and is well tolerated in locally advanced esophageal squamous cell carcinoma (ESCC). And nowadays, no effective biological markers have been identified for predicting the prognosis of patients with ESCC. Platelet-derived growth factor (PDGF) is associated with a po...

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Autores principales: Er, Puchun, Qian, Dong, Zhang, Wencheng, Zhang, Baozhong, Wei, Hui, Zhang, Tian, Chen, Xi, Wang, Yuwen, Zhao, Jingjing, Wang, Qi, Pang, Qingsong, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202496/
https://www.ncbi.nlm.nih.gov/pubmed/32330901
http://dx.doi.org/10.18632/aging.102993
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author Er, Puchun
Qian, Dong
Zhang, Wencheng
Zhang, Baozhong
Wei, Hui
Zhang, Tian
Chen, Xi
Wang, Yuwen
Zhao, Jingjing
Wang, Qi
Pang, Qingsong
Wang, Ping
author_facet Er, Puchun
Qian, Dong
Zhang, Wencheng
Zhang, Baozhong
Wei, Hui
Zhang, Tian
Chen, Xi
Wang, Yuwen
Zhao, Jingjing
Wang, Qi
Pang, Qingsong
Wang, Ping
author_sort Er, Puchun
collection PubMed
description Radiotherapy is the major approach and is well tolerated in locally advanced esophageal squamous cell carcinoma (ESCC). And nowadays, no effective biological markers have been identified for predicting the prognosis of patients with ESCC. Platelet-derived growth factor (PDGF) is associated with a poor prognosis of various malignancies. The present study aimed to assess the effect of PDGF-BB on radiotherapeutic responses of ESCC and the underlying mechanisms of its roles in ESCC. Serum from 68 cases that received neoadjuvant or radical radiotherapy was obtained before and during radiotherapy. Gene expression analyses were validated by enzyme linked immunosorbent assay. The prognosis of patients with significantly reduced PDGF-BB was probably better than that of the others found in the progression-free survival and overall survival groups. Depletion of PDGFB significantly suppressed the proliferation, invasion and migration of cancer cells. Inhibiting PDGFB induced cellular apoptosis and promoted the sensitivity to ionizing radiation (IR). Furthermore, IR inhibited PDGF-BB-induced migration by blocking the PI3K/AKT pathway in ESCC cells. We found that the expression of PDGF-BB provided a possible model for predicting ESCC radiotherapy. It can also be used as a prognostic indicator for locally advanced ESCC that was treated by radiotherapy.
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spelling pubmed-72024962020-05-11 The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy Er, Puchun Qian, Dong Zhang, Wencheng Zhang, Baozhong Wei, Hui Zhang, Tian Chen, Xi Wang, Yuwen Zhao, Jingjing Wang, Qi Pang, Qingsong Wang, Ping Aging (Albany NY) Research Paper Radiotherapy is the major approach and is well tolerated in locally advanced esophageal squamous cell carcinoma (ESCC). And nowadays, no effective biological markers have been identified for predicting the prognosis of patients with ESCC. Platelet-derived growth factor (PDGF) is associated with a poor prognosis of various malignancies. The present study aimed to assess the effect of PDGF-BB on radiotherapeutic responses of ESCC and the underlying mechanisms of its roles in ESCC. Serum from 68 cases that received neoadjuvant or radical radiotherapy was obtained before and during radiotherapy. Gene expression analyses were validated by enzyme linked immunosorbent assay. The prognosis of patients with significantly reduced PDGF-BB was probably better than that of the others found in the progression-free survival and overall survival groups. Depletion of PDGFB significantly suppressed the proliferation, invasion and migration of cancer cells. Inhibiting PDGFB induced cellular apoptosis and promoted the sensitivity to ionizing radiation (IR). Furthermore, IR inhibited PDGF-BB-induced migration by blocking the PI3K/AKT pathway in ESCC cells. We found that the expression of PDGF-BB provided a possible model for predicting ESCC radiotherapy. It can also be used as a prognostic indicator for locally advanced ESCC that was treated by radiotherapy. Impact Journals 2020-04-24 /pmc/articles/PMC7202496/ /pubmed/32330901 http://dx.doi.org/10.18632/aging.102993 Text en Copyright © 2020 Er et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Er, Puchun
Qian, Dong
Zhang, Wencheng
Zhang, Baozhong
Wei, Hui
Zhang, Tian
Chen, Xi
Wang, Yuwen
Zhao, Jingjing
Wang, Qi
Pang, Qingsong
Wang, Ping
The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title_full The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title_fullStr The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title_full_unstemmed The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title_short The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
title_sort expression of pdgf-bb predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202496/
https://www.ncbi.nlm.nih.gov/pubmed/32330901
http://dx.doi.org/10.18632/aging.102993
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