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Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

KEAP1 regulates the cytoprotection induced by NRF2 and has been reported to be a candidate tumor suppressor. Recent evidence has shown that mutations in several driver genes cause aberrant DNA methylation patterns, a hallmark of cancer. However, the correlation between KEAP1 mutations and DNA methyl...

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Detalles Bibliográficos
Autores principales:	Elshaer, Mohamed, ElManawy, Ahmed Islam, Hammad, Ahmed, Namani, Akhileshwar, Wang, Xiu Jun, Tang, Xiuwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202502/ https://www.ncbi.nlm.nih.gov/pubmed/32327612 http://dx.doi.org/10.18632/aging.103068

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