Cargando…
Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and exhibits a high risk of invasion and metastasis. It is urgent to uncover a novel biomarker and clarify the underlying mechanism for ccRCC progression and metastasis. Although accumulating research has demonstra...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202521/ https://www.ncbi.nlm.nih.gov/pubmed/32315986 http://dx.doi.org/10.18632/aging.103091 |
_version_ | 1783529716545748992 |
---|---|
author | Cheng, Gong Yu, Yi Wang, Longwang Pan, Qiufeng |
author_facet | Cheng, Gong Yu, Yi Wang, Longwang Pan, Qiufeng |
author_sort | Cheng, Gong |
collection | PubMed |
description | Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and exhibits a high risk of invasion and metastasis. It is urgent to uncover a novel biomarker and clarify the underlying mechanism for ccRCC progression and metastasis. Although accumulating research has demonstrated that long non-coding RNAs (lncRNAs) play crucial roles in tumor progression, numerous lncRNAs in ccRCC are largely unknown. Therefore, we screened the differentially expressed lncRNAs among several GEO datasets and chose LNC00160 for further investigation. LNC00160 was significantly upregulated in ccRCC and high expression predicted poor prognosis; higher expression of LNC00160 was associated with advanced clinic pathological parameters in TCGA_KIRC Cohort. Knockdown of LNC00160 suppressed malignancy of ccRCC in vitro and in vivo. Correlation analysis and gene set enrichment analysis (GSEA) revealed that LNC00160 might be associated with Wnt signaling pathway, mTOR signaling pathway, fatty acid metabolism and cell cycle. In conclusion, our results demonstrated that LNC00160 acted as an oncogenic gene and a specific prognostic indicator for patients with ccRCC, and that LNC00160 might be a targeted intervention for ccRCC patients in the future. |
format | Online Article Text |
id | pubmed-7202521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-72025212020-05-11 Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma Cheng, Gong Yu, Yi Wang, Longwang Pan, Qiufeng Aging (Albany NY) Research Paper Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and exhibits a high risk of invasion and metastasis. It is urgent to uncover a novel biomarker and clarify the underlying mechanism for ccRCC progression and metastasis. Although accumulating research has demonstrated that long non-coding RNAs (lncRNAs) play crucial roles in tumor progression, numerous lncRNAs in ccRCC are largely unknown. Therefore, we screened the differentially expressed lncRNAs among several GEO datasets and chose LNC00160 for further investigation. LNC00160 was significantly upregulated in ccRCC and high expression predicted poor prognosis; higher expression of LNC00160 was associated with advanced clinic pathological parameters in TCGA_KIRC Cohort. Knockdown of LNC00160 suppressed malignancy of ccRCC in vitro and in vivo. Correlation analysis and gene set enrichment analysis (GSEA) revealed that LNC00160 might be associated with Wnt signaling pathway, mTOR signaling pathway, fatty acid metabolism and cell cycle. In conclusion, our results demonstrated that LNC00160 acted as an oncogenic gene and a specific prognostic indicator for patients with ccRCC, and that LNC00160 might be a targeted intervention for ccRCC patients in the future. Impact Journals 2020-04-21 /pmc/articles/PMC7202521/ /pubmed/32315986 http://dx.doi.org/10.18632/aging.103091 Text en Copyright © 2020 Cheng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Cheng, Gong Yu, Yi Wang, Longwang Pan, Qiufeng Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title | Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title_full | Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title_fullStr | Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title_full_unstemmed | Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title_short | Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
title_sort | overexpression of linc00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202521/ https://www.ncbi.nlm.nih.gov/pubmed/32315986 http://dx.doi.org/10.18632/aging.103091 |
work_keys_str_mv | AT chenggong overexpressionoflinc00160predictspooroutcomeandpromotesprogressionofclearcellrenalcellcarcinoma AT yuyi overexpressionoflinc00160predictspooroutcomeandpromotesprogressionofclearcellrenalcellcarcinoma AT wanglongwang overexpressionoflinc00160predictspooroutcomeandpromotesprogressionofclearcellrenalcellcarcinoma AT panqiufeng overexpressionoflinc00160predictspooroutcomeandpromotesprogressionofclearcellrenalcellcarcinoma |