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Cerebellar Purkinje cell activity modulates aggressive behavior

Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar circuits and patterns of activity that influence a...

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Autores principales: Jackman, Skyler L, Chen, Christopher H, Offermann, Heather L, Drew, Iain R, Harrison, Bailey M, Bowman, Anna M, Flick, Katelyn M, Flaquer, Isabella, Regehr, Wade G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202893/
https://www.ncbi.nlm.nih.gov/pubmed/32343225
http://dx.doi.org/10.7554/eLife.53229
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author Jackman, Skyler L
Chen, Christopher H
Offermann, Heather L
Drew, Iain R
Harrison, Bailey M
Bowman, Anna M
Flick, Katelyn M
Flaquer, Isabella
Regehr, Wade G
author_facet Jackman, Skyler L
Chen, Christopher H
Offermann, Heather L
Drew, Iain R
Harrison, Bailey M
Bowman, Anna M
Flick, Katelyn M
Flaquer, Isabella
Regehr, Wade G
author_sort Jackman, Skyler L
collection PubMed
description Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar circuits and patterns of activity that influence aggression remain unclear. We used optogenetic methods to bidirectionally modulate the activity of spatially-delineated cerebellar Purkinje cells to evaluate the impact on aggression in mice. Increasing Purkinje cell activity in the vermis significantly reduced the frequency of attacks in a resident-intruder assay. Reduced aggression was not a consequence of impaired motor function, because optogenetic stimulation did not alter motor performance. In complementary experiments, optogenetic inhibition of Purkinje cells in the vermis increased the frequency of attacks. These results suggest Purkinje cell activity in the cerebellar vermis regulates aggression, and further support the importance of the cerebellum in driving affective behaviors that could contribute to neurological disorders.
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spelling pubmed-72028932020-05-08 Cerebellar Purkinje cell activity modulates aggressive behavior Jackman, Skyler L Chen, Christopher H Offermann, Heather L Drew, Iain R Harrison, Bailey M Bowman, Anna M Flick, Katelyn M Flaquer, Isabella Regehr, Wade G eLife Neuroscience Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar circuits and patterns of activity that influence aggression remain unclear. We used optogenetic methods to bidirectionally modulate the activity of spatially-delineated cerebellar Purkinje cells to evaluate the impact on aggression in mice. Increasing Purkinje cell activity in the vermis significantly reduced the frequency of attacks in a resident-intruder assay. Reduced aggression was not a consequence of impaired motor function, because optogenetic stimulation did not alter motor performance. In complementary experiments, optogenetic inhibition of Purkinje cells in the vermis increased the frequency of attacks. These results suggest Purkinje cell activity in the cerebellar vermis regulates aggression, and further support the importance of the cerebellum in driving affective behaviors that could contribute to neurological disorders. eLife Sciences Publications, Ltd 2020-04-28 /pmc/articles/PMC7202893/ /pubmed/32343225 http://dx.doi.org/10.7554/eLife.53229 Text en © 2020, Jackman et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Jackman, Skyler L
Chen, Christopher H
Offermann, Heather L
Drew, Iain R
Harrison, Bailey M
Bowman, Anna M
Flick, Katelyn M
Flaquer, Isabella
Regehr, Wade G
Cerebellar Purkinje cell activity modulates aggressive behavior
title Cerebellar Purkinje cell activity modulates aggressive behavior
title_full Cerebellar Purkinje cell activity modulates aggressive behavior
title_fullStr Cerebellar Purkinje cell activity modulates aggressive behavior
title_full_unstemmed Cerebellar Purkinje cell activity modulates aggressive behavior
title_short Cerebellar Purkinje cell activity modulates aggressive behavior
title_sort cerebellar purkinje cell activity modulates aggressive behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202893/
https://www.ncbi.nlm.nih.gov/pubmed/32343225
http://dx.doi.org/10.7554/eLife.53229
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