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COVID-19-Related Stroke
The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a “sepsis-induced coagulopathy” and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) pr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202903/ https://www.ncbi.nlm.nih.gov/pubmed/32378030 http://dx.doi.org/10.1007/s12975-020-00818-9 |
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author | Hess, David C. Eldahshan, Wael Rutkowski, Elizabeth |
author_facet | Hess, David C. Eldahshan, Wael Rutkowski, Elizabeth |
author_sort | Hess, David C. |
collection | PubMed |
description | The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a “sepsis-induced coagulopathy” and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endothelial and smooth muscle cells. ACE2 is a key part of the renin angiotensin system (RAS) and a counterbalance to angiotensin-converting enzyme 1 (ACE1) and angiotensin II. Angiotensin II is proinflammatory, is vasoconstrictive, and promotes organ damage. Depletion of ACE2 by SARS-CoV-2 may tip the balance in favor of the “harmful” ACE1/angiotensin II axis and promote tissue injury including stroke. There is a rationale to continue to treat with tissue plasminogen activator for COVID-19-related stroke and low molecular weight heparinoids may reduce thrombosis and mortality in sepsis-induced coagulopathy. |
format | Online Article Text |
id | pubmed-7202903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-72029032020-05-07 COVID-19-Related Stroke Hess, David C. Eldahshan, Wael Rutkowski, Elizabeth Transl Stroke Res Commentary The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a “sepsis-induced coagulopathy” and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endothelial and smooth muscle cells. ACE2 is a key part of the renin angiotensin system (RAS) and a counterbalance to angiotensin-converting enzyme 1 (ACE1) and angiotensin II. Angiotensin II is proinflammatory, is vasoconstrictive, and promotes organ damage. Depletion of ACE2 by SARS-CoV-2 may tip the balance in favor of the “harmful” ACE1/angiotensin II axis and promote tissue injury including stroke. There is a rationale to continue to treat with tissue plasminogen activator for COVID-19-related stroke and low molecular weight heparinoids may reduce thrombosis and mortality in sepsis-induced coagulopathy. Springer US 2020-05-07 2020 /pmc/articles/PMC7202903/ /pubmed/32378030 http://dx.doi.org/10.1007/s12975-020-00818-9 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Commentary Hess, David C. Eldahshan, Wael Rutkowski, Elizabeth COVID-19-Related Stroke |
title | COVID-19-Related Stroke |
title_full | COVID-19-Related Stroke |
title_fullStr | COVID-19-Related Stroke |
title_full_unstemmed | COVID-19-Related Stroke |
title_short | COVID-19-Related Stroke |
title_sort | covid-19-related stroke |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202903/ https://www.ncbi.nlm.nih.gov/pubmed/32378030 http://dx.doi.org/10.1007/s12975-020-00818-9 |
work_keys_str_mv | AT hessdavidc covid19relatedstroke AT eldahshanwael covid19relatedstroke AT rutkowskielizabeth covid19relatedstroke |