Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes

We successfully prepared water-soluble fullerenol [C(60)(OH)(46)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(60)(OH)(46) with a higher composition of exposed hydroxyl groups had superior two-photon stability...

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Detalles Bibliográficos
Autores principales: Kuo, Wen-Shuo, Wang, Jiu-Yao, Chang, Chia-Yuan, Liu, Jui-Chang, Shao, Yu-Ting, Lin, Yen-Sung, So, Edmund Cheung, Wu, Ping-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203358/
https://www.ncbi.nlm.nih.gov/pubmed/32378063
http://dx.doi.org/10.1186/s11671-020-03329-6
Descripción
Sumario:We successfully prepared water-soluble fullerenol [C(60)(OH)(46)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(60)(OH)(46) with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C(60)(OH)(46) had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C(60)(OH)(46) had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel(−1) with 800 scans and a photoexcited wavelength of 760 nm.

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