Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes

We successfully prepared water-soluble fullerenol [C(60)(OH)(46)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(60)(OH)(46) with a higher composition of exposed hydroxyl groups had superior two-photon stability...

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Autores principales: Kuo, Wen-Shuo, Wang, Jiu-Yao, Chang, Chia-Yuan, Liu, Jui-Chang, Shao, Yu-Ting, Lin, Yen-Sung, So, Edmund Cheung, Wu, Ping-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203358/
https://www.ncbi.nlm.nih.gov/pubmed/32378063
http://dx.doi.org/10.1186/s11671-020-03329-6
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author Kuo, Wen-Shuo
Wang, Jiu-Yao
Chang, Chia-Yuan
Liu, Jui-Chang
Shao, Yu-Ting
Lin, Yen-Sung
So, Edmund Cheung
Wu, Ping-Ching
author_facet Kuo, Wen-Shuo
Wang, Jiu-Yao
Chang, Chia-Yuan
Liu, Jui-Chang
Shao, Yu-Ting
Lin, Yen-Sung
So, Edmund Cheung
Wu, Ping-Ching
author_sort Kuo, Wen-Shuo
collection PubMed
description We successfully prepared water-soluble fullerenol [C(60)(OH)(46)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(60)(OH)(46) with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C(60)(OH)(46) had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C(60)(OH)(46) had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel(−1) with 800 scans and a photoexcited wavelength of 760 nm.
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spelling pubmed-72033582020-05-12 Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes Kuo, Wen-Shuo Wang, Jiu-Yao Chang, Chia-Yuan Liu, Jui-Chang Shao, Yu-Ting Lin, Yen-Sung So, Edmund Cheung Wu, Ping-Ching Nanoscale Res Lett Nano Express We successfully prepared water-soluble fullerenol [C(60)(OH)(46)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(60)(OH)(46) with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C(60)(OH)(46) had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C(60)(OH)(46) had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel(−1) with 800 scans and a photoexcited wavelength of 760 nm. Springer US 2020-05-06 /pmc/articles/PMC7203358/ /pubmed/32378063 http://dx.doi.org/10.1186/s11671-020-03329-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Nano Express
Kuo, Wen-Shuo
Wang, Jiu-Yao
Chang, Chia-Yuan
Liu, Jui-Chang
Shao, Yu-Ting
Lin, Yen-Sung
So, Edmund Cheung
Wu, Ping-Ching
Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title_full Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title_fullStr Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title_full_unstemmed Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title_short Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
title_sort water-soluble fullerenol with hydroxyl group dependence for efficient two-photon excited photodynamic inactivation of infectious microbes
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203358/
https://www.ncbi.nlm.nih.gov/pubmed/32378063
http://dx.doi.org/10.1186/s11671-020-03329-6
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