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Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammaso...

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Autores principales: Oliviero, Francesca, Bindoli, Sara, Scanu, Anna, Feist, Eugen, Doria, Andrea, Galozzi, Paola, Sfriso, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203538/
https://www.ncbi.nlm.nih.gov/pubmed/32426360
http://dx.doi.org/10.3389/fmed.2020.00166
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author Oliviero, Francesca
Bindoli, Sara
Scanu, Anna
Feist, Eugen
Doria, Andrea
Galozzi, Paola
Sfriso, Paolo
author_facet Oliviero, Francesca
Bindoli, Sara
Scanu, Anna
Feist, Eugen
Doria, Andrea
Galozzi, Paola
Sfriso, Paolo
author_sort Oliviero, Francesca
collection PubMed
description Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects.
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spelling pubmed-72035382020-05-18 Autoinflammatory Mechanisms in Crystal-Induced Arthritis Oliviero, Francesca Bindoli, Sara Scanu, Anna Feist, Eugen Doria, Andrea Galozzi, Paola Sfriso, Paolo Front Med (Lausanne) Medicine Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects. Frontiers Media S.A. 2020-04-30 /pmc/articles/PMC7203538/ /pubmed/32426360 http://dx.doi.org/10.3389/fmed.2020.00166 Text en Copyright © 2020 Oliviero, Bindoli, Scanu, Feist, Doria, Galozzi and Sfriso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Oliviero, Francesca
Bindoli, Sara
Scanu, Anna
Feist, Eugen
Doria, Andrea
Galozzi, Paola
Sfriso, Paolo
Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title_full Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title_fullStr Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title_full_unstemmed Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title_short Autoinflammatory Mechanisms in Crystal-Induced Arthritis
title_sort autoinflammatory mechanisms in crystal-induced arthritis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203538/
https://www.ncbi.nlm.nih.gov/pubmed/32426360
http://dx.doi.org/10.3389/fmed.2020.00166
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