Cargando…
Autoinflammatory Mechanisms in Crystal-Induced Arthritis
Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammaso...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203538/ https://www.ncbi.nlm.nih.gov/pubmed/32426360 http://dx.doi.org/10.3389/fmed.2020.00166 |
_version_ | 1783529889894236160 |
---|---|
author | Oliviero, Francesca Bindoli, Sara Scanu, Anna Feist, Eugen Doria, Andrea Galozzi, Paola Sfriso, Paolo |
author_facet | Oliviero, Francesca Bindoli, Sara Scanu, Anna Feist, Eugen Doria, Andrea Galozzi, Paola Sfriso, Paolo |
author_sort | Oliviero, Francesca |
collection | PubMed |
description | Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects. |
format | Online Article Text |
id | pubmed-7203538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72035382020-05-18 Autoinflammatory Mechanisms in Crystal-Induced Arthritis Oliviero, Francesca Bindoli, Sara Scanu, Anna Feist, Eugen Doria, Andrea Galozzi, Paola Sfriso, Paolo Front Med (Lausanne) Medicine Crystal-induced arthritides have been classified as “type-1 autoinflammatory diseases” for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term “auto” refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects. Frontiers Media S.A. 2020-04-30 /pmc/articles/PMC7203538/ /pubmed/32426360 http://dx.doi.org/10.3389/fmed.2020.00166 Text en Copyright © 2020 Oliviero, Bindoli, Scanu, Feist, Doria, Galozzi and Sfriso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Oliviero, Francesca Bindoli, Sara Scanu, Anna Feist, Eugen Doria, Andrea Galozzi, Paola Sfriso, Paolo Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title | Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title_full | Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title_fullStr | Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title_full_unstemmed | Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title_short | Autoinflammatory Mechanisms in Crystal-Induced Arthritis |
title_sort | autoinflammatory mechanisms in crystal-induced arthritis |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203538/ https://www.ncbi.nlm.nih.gov/pubmed/32426360 http://dx.doi.org/10.3389/fmed.2020.00166 |
work_keys_str_mv | AT olivierofrancesca autoinflammatorymechanismsincrystalinducedarthritis AT bindolisara autoinflammatorymechanismsincrystalinducedarthritis AT scanuanna autoinflammatorymechanismsincrystalinducedarthritis AT feisteugen autoinflammatorymechanismsincrystalinducedarthritis AT doriaandrea autoinflammatorymechanismsincrystalinducedarthritis AT galozzipaola autoinflammatorymechanismsincrystalinducedarthritis AT sfrisopaolo autoinflammatorymechanismsincrystalinducedarthritis |