New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice

In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include l...

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Detalles Bibliográficos
Autores principales: List, Edward O., Berryman, Darlene E., Jensen, Elizabeth A., Kulkarni, Prateek, McKenna, Savannah, Kopchick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203760/
https://www.ncbi.nlm.nih.gov/pubmed/31939480
http://dx.doi.org/10.20945/2359-3997000000185
Descripción
Sumario:In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue “global”. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67

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