New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice

In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include l...

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Detalles Bibliográficos
Autores principales: List, Edward O., Berryman, Darlene E., Jensen, Elizabeth A., Kulkarni, Prateek, McKenna, Savannah, Kopchick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203760/
https://www.ncbi.nlm.nih.gov/pubmed/31939480
http://dx.doi.org/10.20945/2359-3997000000185
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author List, Edward O.
Berryman, Darlene E.
Jensen, Elizabeth A.
Kulkarni, Prateek
McKenna, Savannah
Kopchick, John J.
author_facet List, Edward O.
Berryman, Darlene E.
Jensen, Elizabeth A.
Kulkarni, Prateek
McKenna, Savannah
Kopchick, John J.
author_sort List, Edward O.
collection PubMed
description In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue “global”. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67
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spelling pubmed-72037602020-05-07 New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice List, Edward O. Berryman, Darlene E. Jensen, Elizabeth A. Kulkarni, Prateek McKenna, Savannah Kopchick, John J. Arch Endocrinol Metab Review In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue “global”. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67 Sociedade Brasileira de Endocrinologia e Metabologia 2019-11-01 /pmc/articles/PMC7203760/ /pubmed/31939480 http://dx.doi.org/10.20945/2359-3997000000185 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
List, Edward O.
Berryman, Darlene E.
Jensen, Elizabeth A.
Kulkarni, Prateek
McKenna, Savannah
Kopchick, John J.
New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title_full New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title_fullStr New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title_full_unstemmed New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title_short New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
title_sort new insights of growth hormone (gh) actions from tissue-specific gh receptor knockouts in mice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203760/
https://www.ncbi.nlm.nih.gov/pubmed/31939480
http://dx.doi.org/10.20945/2359-3997000000185
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