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Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients
BACKGROUND: Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance. METHODS: We obtained data r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203881/ https://www.ncbi.nlm.nih.gov/pubmed/32375664 http://dx.doi.org/10.1186/s12882-020-01831-8 |
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author | Lee, Yu Ho Kim, Jin Sug Jung, Su-Woong Hwang, Hyeon Seok Moon, Ju-Young Jeong, Kyung-Hwan Lee, Sang-Ho Lee, So-Young Ko, Gang Jee Lee, Dong-Young Lee, Hong joo Kim, Yang Gyun |
author_facet | Lee, Yu Ho Kim, Jin Sug Jung, Su-Woong Hwang, Hyeon Seok Moon, Ju-Young Jeong, Kyung-Hwan Lee, Sang-Ho Lee, So-Young Ko, Gang Jee Lee, Dong-Young Lee, Hong joo Kim, Yang Gyun |
author_sort | Lee, Yu Ho |
collection | PubMed |
description | BACKGROUND: Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance. METHODS: We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia. RESULTS: The prevalence of low gait speed and handgrip strength was 28.2 and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index score, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with different determining factors (older age, the presence of diabetes, and lower serum albumin level for low gait speed, and lower body mass index and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risks for all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024). Elderly patients with low gait speed and handgrip strength were at the highest risk for poor clinical outcomes. CONCLUSION: Gait speed and handgrip strength reflected distinctive aspects of patient characteristics and the use of both factors improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator of poor patient outcomes than is handgrip strength. |
format | Online Article Text |
id | pubmed-7203881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72038812020-05-09 Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients Lee, Yu Ho Kim, Jin Sug Jung, Su-Woong Hwang, Hyeon Seok Moon, Ju-Young Jeong, Kyung-Hwan Lee, Sang-Ho Lee, So-Young Ko, Gang Jee Lee, Dong-Young Lee, Hong joo Kim, Yang Gyun BMC Nephrol Research Article BACKGROUND: Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance. METHODS: We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia. RESULTS: The prevalence of low gait speed and handgrip strength was 28.2 and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index score, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with different determining factors (older age, the presence of diabetes, and lower serum albumin level for low gait speed, and lower body mass index and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risks for all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024). Elderly patients with low gait speed and handgrip strength were at the highest risk for poor clinical outcomes. CONCLUSION: Gait speed and handgrip strength reflected distinctive aspects of patient characteristics and the use of both factors improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator of poor patient outcomes than is handgrip strength. BioMed Central 2020-05-06 /pmc/articles/PMC7203881/ /pubmed/32375664 http://dx.doi.org/10.1186/s12882-020-01831-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Lee, Yu Ho Kim, Jin Sug Jung, Su-Woong Hwang, Hyeon Seok Moon, Ju-Young Jeong, Kyung-Hwan Lee, Sang-Ho Lee, So-Young Ko, Gang Jee Lee, Dong-Young Lee, Hong joo Kim, Yang Gyun Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title | Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title_full | Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title_fullStr | Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title_full_unstemmed | Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title_short | Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
title_sort | gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203881/ https://www.ncbi.nlm.nih.gov/pubmed/32375664 http://dx.doi.org/10.1186/s12882-020-01831-8 |
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