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Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation

[Image: see text] DNA gyrase and topoisomerase IV are well-validated pharmacological targets, and quinolone antibacterial drugs are marketed as their representative inhibitors. However, in recent years, resistance to these existing drugs has become a problem, and new chemical classes of antibiotics...

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Detalles Bibliográficos
Autores principales:	Ushiyama, Fumihito, Amada, Hideaki, Takeuchi, Tomoki, Tanaka-Yamamoto, Nozomi, Kanazawa, Harumi, Nakano, Koichiro, Mima, Masashi, Masuko, Aiko, Takata, Iichiro, Hitaka, Kosuke, Iwamoto, Kunihiko, Sugiyama, Hiroyuki, Ohtake, Norikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203957/ https://www.ncbi.nlm.nih.gov/pubmed/32391502 http://dx.doi.org/10.1021/acsomega.0c00865

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