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Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6

BACKGROUND: Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a novel strategy for enhanced wound repair. Saliva is known to accelerate wound healing, but the underlying mechanisms remain unclear. R...

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Autores principales: Mi, Bobin, Chen, Lang, Xiong, Yuan, Yan, Chenchen, Xue, Hang, Panayi, Adriana C., Liu, Jing, Hu, Liangcong, Hu, Yiqiang, Cao, Faqi, Sun, Yun, Zhou, Wu, Liu, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203970/
https://www.ncbi.nlm.nih.gov/pubmed/32375794
http://dx.doi.org/10.1186/s12951-020-00624-3
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author Mi, Bobin
Chen, Lang
Xiong, Yuan
Yan, Chenchen
Xue, Hang
Panayi, Adriana C.
Liu, Jing
Hu, Liangcong
Hu, Yiqiang
Cao, Faqi
Sun, Yun
Zhou, Wu
Liu, Guohui
author_facet Mi, Bobin
Chen, Lang
Xiong, Yuan
Yan, Chenchen
Xue, Hang
Panayi, Adriana C.
Liu, Jing
Hu, Liangcong
Hu, Yiqiang
Cao, Faqi
Sun, Yun
Zhou, Wu
Liu, Guohui
author_sort Mi, Bobin
collection PubMed
description BACKGROUND: Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a novel strategy for enhanced wound repair. Saliva is known to accelerate wound healing, but the underlying mechanisms remain unclear. RESULTS: Our results have demonstrated that saliva-derived exosomes (saliva-Exos) induce human umbilical vein endothelial cells (HUVEC) proliferation, migration, and angiogenesis in vitro, and promote cutaneous wound healing in vivo. Further experiments documented that Ubiquitin-conjugating enzyme E2O (UBE2O) is one of the main mRNAs of saliva-Exos, and activation of UBE2O has effects similar to those of saliva-Exos, both in vitro and in vivo. Mechanistically, UBE2O decreases the level of SMAD family member 6 (SMAD6), thereby activating bone morphogenetic protein 2 (BMP2), which, in turn, induces angiogenesis. CONCLUSIONS: The present work suggests that administration of saliva-Exos and UBE2O represents a promising strategy for enhancing wound healing through promotion of angiogenesis.
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spelling pubmed-72039702020-05-12 Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6 Mi, Bobin Chen, Lang Xiong, Yuan Yan, Chenchen Xue, Hang Panayi, Adriana C. Liu, Jing Hu, Liangcong Hu, Yiqiang Cao, Faqi Sun, Yun Zhou, Wu Liu, Guohui J Nanobiotechnology Research BACKGROUND: Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a novel strategy for enhanced wound repair. Saliva is known to accelerate wound healing, but the underlying mechanisms remain unclear. RESULTS: Our results have demonstrated that saliva-derived exosomes (saliva-Exos) induce human umbilical vein endothelial cells (HUVEC) proliferation, migration, and angiogenesis in vitro, and promote cutaneous wound healing in vivo. Further experiments documented that Ubiquitin-conjugating enzyme E2O (UBE2O) is one of the main mRNAs of saliva-Exos, and activation of UBE2O has effects similar to those of saliva-Exos, both in vitro and in vivo. Mechanistically, UBE2O decreases the level of SMAD family member 6 (SMAD6), thereby activating bone morphogenetic protein 2 (BMP2), which, in turn, induces angiogenesis. CONCLUSIONS: The present work suggests that administration of saliva-Exos and UBE2O represents a promising strategy for enhancing wound healing through promotion of angiogenesis. BioMed Central 2020-05-06 /pmc/articles/PMC7203970/ /pubmed/32375794 http://dx.doi.org/10.1186/s12951-020-00624-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mi, Bobin
Chen, Lang
Xiong, Yuan
Yan, Chenchen
Xue, Hang
Panayi, Adriana C.
Liu, Jing
Hu, Liangcong
Hu, Yiqiang
Cao, Faqi
Sun, Yun
Zhou, Wu
Liu, Guohui
Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title_full Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title_fullStr Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title_full_unstemmed Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title_short Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
title_sort saliva exosomes-derived ube2o mrna promotes angiogenesis in cutaneous wounds by targeting smad6
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203970/
https://www.ncbi.nlm.nih.gov/pubmed/32375794
http://dx.doi.org/10.1186/s12951-020-00624-3
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