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Complexes of N- and O-Donor Ligands as Potential Urease Inhibitors

[Image: see text] We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (BTA), thiobarbituric acid (TBA), isoniazid (INZ), and nicotinamide (NCA) ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of ana...

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Detalles Bibliográficos
Autores principales: Shah, Syed Raza, Shah, Zarbad, Khiat, Mohammed, Khan, Ajmal, Hill, Leila R., Khan, Shakeel, Hussain, Javid, Csuk, René, Anwar, Muhammad U., Al-Harrasi, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203987/
https://www.ncbi.nlm.nih.gov/pubmed/32391508
http://dx.doi.org/10.1021/acsomega.0c01089
Descripción
Sumario:[Image: see text] We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (BTA), thiobarbituric acid (TBA), isoniazid (INZ), and nicotinamide (NCA) ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of analytical techniques including infra-red and UV–vis spectroscopy, (1)H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. We describe two mononuclear complexes with a general formula {[M(NCA)(2)(H(2)O)(4)](BTA)(2)(H(2)O)}, where M = Co (1) and Zn (2), a mononuclear complex {[Ni(NCA)(2)(H(2)O)(4)](TBA)(2)(H(2)O)} (3), and two polymeric chains of a general formula {[M(INZ) (H(2)O)(3)](BTA)(2)(H(2)O)(3)}, where M = Co (4) and Zn (5). These complexes displayed significant urease enzyme inhibition with IC(50) values in the range of 3.9–19.9 μM.