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Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF

BACKGROUND: The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationship of TL1A to disease duration, activity, and resp...

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Autores principales: Song, Yun-Jeong, Choi, In Ah., Meylan, Françoise, Demoruelle, M. Kristen, Farley, Taylor, Richard, Arianne C., Hawley, Eric, Botson, John, Hong, Yoo Jin, Lee, Eun Young, Mian, Sabina R., Hamilton, Bartlett C., Thiele, Geoffrey M., Mikuls, Ted R., Gara, Naveen, Ward, Chris D., Lamberth, Sarah, Deane, Kevin D., Heller, Theo, Ward, Michael M., Lee, David M., Migone, Thi-Sau, Stohl, William, O’Dell, James R., Norris, Jill M., Holers, V. Michael, Gregersen, Peter, Song, Yeong-Wook, Siegel, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204024/
https://www.ncbi.nlm.nih.gov/pubmed/32381123
http://dx.doi.org/10.1186/s13075-020-02198-9
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author Song, Yun-Jeong
Choi, In Ah.
Meylan, Françoise
Demoruelle, M. Kristen
Farley, Taylor
Richard, Arianne C.
Hawley, Eric
Botson, John
Hong, Yoo Jin
Lee, Eun Young
Mian, Sabina R.
Hamilton, Bartlett C.
Thiele, Geoffrey M.
Mikuls, Ted R.
Gara, Naveen
Ward, Chris D.
Lamberth, Sarah
Deane, Kevin D.
Heller, Theo
Ward, Michael M.
Lee, David M.
Migone, Thi-Sau
Stohl, William
O’Dell, James R.
Norris, Jill M.
Holers, V. Michael
Gregersen, Peter
Song, Yeong-Wook
Siegel, Richard M.
author_facet Song, Yun-Jeong
Choi, In Ah.
Meylan, Françoise
Demoruelle, M. Kristen
Farley, Taylor
Richard, Arianne C.
Hawley, Eric
Botson, John
Hong, Yoo Jin
Lee, Eun Young
Mian, Sabina R.
Hamilton, Bartlett C.
Thiele, Geoffrey M.
Mikuls, Ted R.
Gara, Naveen
Ward, Chris D.
Lamberth, Sarah
Deane, Kevin D.
Heller, Theo
Ward, Michael M.
Lee, David M.
Migone, Thi-Sau
Stohl, William
O’Dell, James R.
Norris, Jill M.
Holers, V. Michael
Gregersen, Peter
Song, Yeong-Wook
Siegel, Richard M.
author_sort Song, Yun-Jeong
collection PubMed
description BACKGROUND: The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationship of TL1A to disease duration, activity, and response to anti-TNF and other therapies in RA is not clear. METHODS: We measured soluble TL1A in synovial fluid (SF), serum, or plasma from RA first-degree relatives (FDRs) and in early RA and established disease. We measured the effects of anti-TNF and methotrexate (MTX) therapy on circulating TL1A from multiple independent RA treatment trials. We also determined the ability of a blocking anti-TL1A antibody to inhibit clinical disease and articular bone destruction in the murine collagen-induced arthritis (CIA) model of human RA. RESULTS: Soluble TL1A was specifically elevated in the blood and SF of patients with RA compared to patients with other diseases and was elevated early in disease and in at-risk anti-cyclic citrullinated peptide (CCP) (+) first-degree relatives (FDRs). Therapeutic TNF inhibition reduced serum TL1A in both responders and non-responders, whereas TL1A declined following MTX treatment only in responders. In murine CIA, TL1A blockade was clinically efficacious and reduced bone erosions. CONCLUSIONS: TL1A is specifically elevated in RA from early in the disease course and in at-risk FDRs. The decline in TL1A after TNF blockade suggests that TL1A levels may be a useful biomarker for TNF activity in RA. These results support the further investigation of the relationship between TL1A and TNF and TL1A blockade as a potential therapeutic strategy in RA.
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spelling pubmed-72040242020-05-12 Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF Song, Yun-Jeong Choi, In Ah. Meylan, Françoise Demoruelle, M. Kristen Farley, Taylor Richard, Arianne C. Hawley, Eric Botson, John Hong, Yoo Jin Lee, Eun Young Mian, Sabina R. Hamilton, Bartlett C. Thiele, Geoffrey M. Mikuls, Ted R. Gara, Naveen Ward, Chris D. Lamberth, Sarah Deane, Kevin D. Heller, Theo Ward, Michael M. Lee, David M. Migone, Thi-Sau Stohl, William O’Dell, James R. Norris, Jill M. Holers, V. Michael Gregersen, Peter Song, Yeong-Wook Siegel, Richard M. Arthritis Res Ther Research Article BACKGROUND: The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationship of TL1A to disease duration, activity, and response to anti-TNF and other therapies in RA is not clear. METHODS: We measured soluble TL1A in synovial fluid (SF), serum, or plasma from RA first-degree relatives (FDRs) and in early RA and established disease. We measured the effects of anti-TNF and methotrexate (MTX) therapy on circulating TL1A from multiple independent RA treatment trials. We also determined the ability of a blocking anti-TL1A antibody to inhibit clinical disease and articular bone destruction in the murine collagen-induced arthritis (CIA) model of human RA. RESULTS: Soluble TL1A was specifically elevated in the blood and SF of patients with RA compared to patients with other diseases and was elevated early in disease and in at-risk anti-cyclic citrullinated peptide (CCP) (+) first-degree relatives (FDRs). Therapeutic TNF inhibition reduced serum TL1A in both responders and non-responders, whereas TL1A declined following MTX treatment only in responders. In murine CIA, TL1A blockade was clinically efficacious and reduced bone erosions. CONCLUSIONS: TL1A is specifically elevated in RA from early in the disease course and in at-risk FDRs. The decline in TL1A after TNF blockade suggests that TL1A levels may be a useful biomarker for TNF activity in RA. These results support the further investigation of the relationship between TL1A and TNF and TL1A blockade as a potential therapeutic strategy in RA. BioMed Central 2020-05-07 2020 /pmc/articles/PMC7204024/ /pubmed/32381123 http://dx.doi.org/10.1186/s13075-020-02198-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Song, Yun-Jeong
Choi, In Ah.
Meylan, Françoise
Demoruelle, M. Kristen
Farley, Taylor
Richard, Arianne C.
Hawley, Eric
Botson, John
Hong, Yoo Jin
Lee, Eun Young
Mian, Sabina R.
Hamilton, Bartlett C.
Thiele, Geoffrey M.
Mikuls, Ted R.
Gara, Naveen
Ward, Chris D.
Lamberth, Sarah
Deane, Kevin D.
Heller, Theo
Ward, Michael M.
Lee, David M.
Migone, Thi-Sau
Stohl, William
O’Dell, James R.
Norris, Jill M.
Holers, V. Michael
Gregersen, Peter
Song, Yeong-Wook
Siegel, Richard M.
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title_full Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title_fullStr Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title_full_unstemmed Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title_short Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
title_sort circulating tnf-like protein 1a (tl1a) is elevated early in rheumatoid arthritis and depends on tnf
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204024/
https://www.ncbi.nlm.nih.gov/pubmed/32381123
http://dx.doi.org/10.1186/s13075-020-02198-9
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