RNA N(6)-Methyladenosine Modifications and the Immune Response

N(6)-methyladenosine (m(6)A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m(6)A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m(6)A modification ha...

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Detalles Bibliográficos
Autores principales: Wang, Ya-Nan, Yu, Chen-Yang, Jin, Hong-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204177/
https://www.ncbi.nlm.nih.gov/pubmed/32411802
http://dx.doi.org/10.1155/2020/6327614
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author Wang, Ya-Nan
Yu, Chen-Yang
Jin, Hong-Zhong
author_facet Wang, Ya-Nan
Yu, Chen-Yang
Jin, Hong-Zhong
author_sort Wang, Ya-Nan
collection PubMed
description N(6)-methyladenosine (m(6)A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m(6)A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m(6)A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m(6)A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m(6)A modifications in the innate immune response, adaptive immune response, and viral infection.
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spelling pubmed-72041772020-05-14 RNA N(6)-Methyladenosine Modifications and the Immune Response Wang, Ya-Nan Yu, Chen-Yang Jin, Hong-Zhong J Immunol Res Review Article N(6)-methyladenosine (m(6)A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m(6)A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m(6)A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m(6)A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m(6)A modifications in the innate immune response, adaptive immune response, and viral infection. Hindawi 2020-01-21 /pmc/articles/PMC7204177/ /pubmed/32411802 http://dx.doi.org/10.1155/2020/6327614 Text en Copyright © 2020 Ya-Nan Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Ya-Nan
Yu, Chen-Yang
Jin, Hong-Zhong
RNA N(6)-Methyladenosine Modifications and the Immune Response
title RNA N(6)-Methyladenosine Modifications and the Immune Response
title_full RNA N(6)-Methyladenosine Modifications and the Immune Response
title_fullStr RNA N(6)-Methyladenosine Modifications and the Immune Response
title_full_unstemmed RNA N(6)-Methyladenosine Modifications and the Immune Response
title_short RNA N(6)-Methyladenosine Modifications and the Immune Response
title_sort rna n(6)-methyladenosine modifications and the immune response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204177/
https://www.ncbi.nlm.nih.gov/pubmed/32411802
http://dx.doi.org/10.1155/2020/6327614
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