Cargando…

Efficacy, safety, and tolerability of combined pirfenidone and N-acetylcysteine therapy: a systematic review and meta-analysis

BACKGROUND: While antifibrotic drugs significantly decrease lung function decline in idiopathic pulmonary fibrosis (IPF), there is still an unmet need to halt disease progression. Antioxidative therapy with N-acetylcysteine (NAC) is considered a potential additional therapy that can be combined with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Hanyu, Yin, Dawei, Bonella, Francesco, Kreuter, Michael, Oltmanns, Ute, Li, Xuren, Peng, Shouchun, Wei, Luqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204217/ https://www.ncbi.nlm.nih.gov/pubmed/32380989 http://dx.doi.org/10.1186/s12890-020-1121-2

Ejemplares similares

Efficacy of N-acetylcysteine plus pirfenidone in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
por: Zhang, Xiu-Li, et al.
Publicado: (2023)

Pirfenidone: is it tolerable?
por: Lara, Abigail, et al.
Publicado: (2016)

Pharmacological treatment of idiopathic pulmonary fibrosis – preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine
por: Myllärniemi, Marjukka, et al.
Publicado: (2015)

Updated Evaluation of the Safety, Efficacy and Tolerability of Pirfenidone in the Treatment of Idiopathic Pulmonary Fibrosis
por: Gulati, Swati, et al.
Publicado: (2020)

Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis
por: Takeda, Yoshito, et al.
Publicado: (2014)

Safety and tolerability of pirfenidone in asbestosis: a prospective multicenter study
por: Miedema, Jelle R., et al.
Publicado: (2022)

Real-world experiences: Efficacy and tolerability of pirfenidone in clinical practice
por: Fang, Chuling, et al.
Publicado: (2020)

Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on pulmonary fibrosis in rat idiopathic pulmonary fibrosis models
por: Yu, Wencheng, et al.
Publicado: (2016)

Pirfenidone: an update on clinical trial data and insights from everyday practice
por: Kreuter, Michael
Publicado: (2014)

Efficacy and Safety of N-Acetylcysteine for Chronic Obstructive Pulmonary Disease and Chronic Bronchitis
por: Zhang, Li, et al.
Publicado: (2022)

Safety of nintedanib added to pirfenidone treatment for idiopathic pulmonary fibrosis
por: Flaherty, Kevin R., et al.
Publicado: (2018)

Activity of N-Acetylcysteine Alone and in Combination with Colistin against Pseudomonas aeruginosa Biofilms and Transcriptomic Response to N-Acetylcysteine Exposure
por: Valzano, Felice, et al.
Publicado: (2022)

Comparison of Longevity in Patients with Idiopathic Pulmonary Fibrosis Using Pirfenidone Versus Triple Therapy with Prednisolone, Azathioprine, and Acetylcysteine
por: Asl, Mobin Soleimanian, et al.
Publicado: (2023)

Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study
por: Çavuş, Umut Yücel, et al.
Publicado: (2023)

In Vitro Antimicrobial Activity of N-Acetylcysteine against Pathogens Most Commonly Associated with Infectious Keratitis in Dogs and Cats
por: Walter, Hanna, et al.
Publicado: (2023)

The Efficacy and Safety of Long-term Pirfenidone Therapy in Patients with Idiopathic Pulmonary Fibrosis
por: Ogawa, Kazumasa, et al.
Publicado: (2018)

South–West of England’s Experience of the Safety and Tolerability Pirfenidone and Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)
por: Barratt, Shaney L., et al.
Publicado: (2018)

Analysis of the safety and efficacy of different plasma concentrations of pirfenidone in patients with idiopathic pulmonary fibrosis
por: Li, Hui, et al.
Publicado: (2022)

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis and its effect on exercise tolerance and pulmonary function
por: Guo, Xiuzhi, et al.
Publicado: (2020)

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma
por: Eshraghi, Adrien A., et al.
Publicado: (2020)

A phase II study on safety and efficacy of high-dose N-acetylcysteine in patients with cystic fibrosis
por: Dauletbaev, N, et al.
Publicado: (2009)

Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta-analysis
por: Feng, Fanchao, et al.
Publicado: (2019)

Pirfenidone vs. nintedanib in patients with idiopathic pulmonary fibrosis: a retrospective cohort study
por: Marijic, Pavo, et al.
Publicado: (2021)

Effect of pirfenidone on breathlessness in patients with idiopathic pulmonary fibrosis
por: Glassberg, Marilyn K., et al.
Publicado: (2019)

N-acetylcysteine in the Treatment of Trichotillomania
por: Rodrigues-Barata, Ana Rita, et al.
Publicado: (2012)

N-acetylcystein in dengue hepatitis
por: Wiwanitkit, Viroj
Publicado: (2014)

Protonation Equilibria of N-Acetylcysteine
por: Fazary, Ahmed E., et al.
Publicado: (2020)

GSH rescue by N-acetylcysteine
por: Ruffmann, R., et al.
Publicado: (1991)

Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial
por: Behr, Jürgen, et al.
Publicado: (2017)

Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis
por: Lancaster, Lisa H., et al.
Publicado: (2017)

Systematic Review of Human and Animal Studies Examining the Efficacy and Safety of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) in Traumatic Brain Injury: Impact on Neurofunctional Outcome and Biomarkers of Oxidative Stress and Inflammation
por: Bhatti, Junaid, et al.
Publicado: (2018)

Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis
por: Sakayori, Masashi, et al.
Publicado: (2019)

Clinical efficacy of budesonide combined with acetylcysteine in the treatment of mycoplasma pneumonia infection
por: Chen, Jing, et al.
Publicado: (2023)

Efficacy and adverse events of pirfenidone in treating idiopathic pulmonary fibrosis
por: Ren, Hui, et al.
Publicado: (2017)

Protective efficacy of pirfenidone in rats with pulmonary fibrosis induced by bleomycin
por: Demirkol, Barış, et al.
Publicado: (2023)

Efficacy of dexamethasone and N-acetylcysteine combination in preventing post-embolization syndrome after transarterial chemoembolization in hepatocellular carcinoma
por: Simasingha, Nitipon, et al.
Publicado: (2023)

Safety of N-Acetylcysteine at High Doses in Chronic Respiratory Diseases: A Review
por: Calverley, Peter, et al.
Publicado: (2020)

Comparison between theophylline, N-acetylcysteine, and theophylline plus N-acetylcysteine for the prevention of contrast-induced nephropathy
por: Arabmomeni, Morteza, et al.
Publicado: (2015)

Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose
por: Pettie, Janice M., et al.
Publicado: (2019)

Pirfenidone for Idiopathic Pulmonary Fibrosis and Beyond
por: Aimo, Alberto, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8hdig2ktuafe1qldcbt9p4rpp4