A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice

A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous d...

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Autores principales: Gardner, Murray B., Henderson, Brian E., Officer, J. Earle, Rongey, Robert W., Parker, John C., Oliver, Cynthia, Estes, John D., Huebner, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 1973
Materias:
Experimental Investigations on Animals
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204280/
https://www.ncbi.nlm.nih.gov/pubmed/4355605
http://dx.doi.org/10.1093/jnci/51.4.1243
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author Gardner, Murray B.
Henderson, Brian E.
Officer, J. Earle
Rongey, Robert W.
Parker, John C.
Oliver, Cynthia
Estes, John D.
Huebner, Robert J.
author_facet Gardner, Murray B.
Henderson, Brian E.
Officer, J. Earle
Rongey, Robert W.
Parker, John C.
Oliver, Cynthia
Estes, John D.
Huebner, Robert J.
author_sort Gardner, Murray B.
collection PubMed
description A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord.
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spelling pubmed-72042802020-05-08 A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice Gardner, Murray B. Henderson, Brian E. Officer, J. Earle Rongey, Robert W. Parker, John C. Oliver, Cynthia Estes, John D. Huebner, Robert J. J Natl Cancer Inst Experimental Investigations on Animals A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord. Oxford University Press 1973-10-01 /pmc/articles/PMC7204280/ /pubmed/4355605 http://dx.doi.org/10.1093/jnci/51.4.1243 Text en https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Experimental Investigations on Animals
Gardner, Murray B.
Henderson, Brian E.
Officer, J. Earle
Rongey, Robert W.
Parker, John C.
Oliver, Cynthia
Estes, John D.
Huebner, Robert J.
A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title_full A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title_fullStr A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title_full_unstemmed A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title_short A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice
title_sort spontaneous lower motor neuron disease apparently caused by indigenous type-c rna virus in wild mice
topic Experimental Investigations on Animals
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204280/
https://www.ncbi.nlm.nih.gov/pubmed/4355605
http://dx.doi.org/10.1093/jnci/51.4.1243
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