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Development and validation of a five-immune gene prognostic risk model in colon cancer

BACKGROUND: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to construct a prognostic risk model based on immune genes for the...

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Autores principales: Chen, Haitao, Luo, Jun, Guo, Jianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204296/
https://www.ncbi.nlm.nih.gov/pubmed/32375704
http://dx.doi.org/10.1186/s12885-020-06799-0
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author Chen, Haitao
Luo, Jun
Guo, Jianchun
author_facet Chen, Haitao
Luo, Jun
Guo, Jianchun
author_sort Chen, Haitao
collection PubMed
description BACKGROUND: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to construct a prognostic risk model based on immune genes for the early diagnosis and accurate prognostic prediction of colon cancer. METHODS: Transcriptomic data and clinical data were downloaded from The Cancer Genome Atlas database. Immune genes were obtained from the ImmPort database. Differentially expressed (DE) immune genes between 473 colon cancer and 41 adjacent normal tissues were identified. The entire cohort was randomly divided into the training and testing cohort. The training cohort was used to construct the prognostic model. The testing and entire cohorts were used to validate the model. The clinical utility of the model and its correlation with immune cell infiltration were analyzed. RESULTS: A total of 333 DE immune genes (176 up-regulated and 157 down-regulated) were detected. We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model was approved to be an independent prognostic variable, which was more accurate than age and the pathological stage for predicting overall survival at five years. Besides, as the risk score increased, the content of CD8+ T cells in colon cancer was decreased. CONCLUSIONS: We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model could be used as an instrumental variable in the prognosis prediction of colon cancer.
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spelling pubmed-72042962020-05-14 Development and validation of a five-immune gene prognostic risk model in colon cancer Chen, Haitao Luo, Jun Guo, Jianchun BMC Cancer Research Article BACKGROUND: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to construct a prognostic risk model based on immune genes for the early diagnosis and accurate prognostic prediction of colon cancer. METHODS: Transcriptomic data and clinical data were downloaded from The Cancer Genome Atlas database. Immune genes were obtained from the ImmPort database. Differentially expressed (DE) immune genes between 473 colon cancer and 41 adjacent normal tissues were identified. The entire cohort was randomly divided into the training and testing cohort. The training cohort was used to construct the prognostic model. The testing and entire cohorts were used to validate the model. The clinical utility of the model and its correlation with immune cell infiltration were analyzed. RESULTS: A total of 333 DE immune genes (176 up-regulated and 157 down-regulated) were detected. We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model was approved to be an independent prognostic variable, which was more accurate than age and the pathological stage for predicting overall survival at five years. Besides, as the risk score increased, the content of CD8+ T cells in colon cancer was decreased. CONCLUSIONS: We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model could be used as an instrumental variable in the prognosis prediction of colon cancer. BioMed Central 2020-05-06 /pmc/articles/PMC7204296/ /pubmed/32375704 http://dx.doi.org/10.1186/s12885-020-06799-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Chen, Haitao
Luo, Jun
Guo, Jianchun
Development and validation of a five-immune gene prognostic risk model in colon cancer
title Development and validation of a five-immune gene prognostic risk model in colon cancer
title_full Development and validation of a five-immune gene prognostic risk model in colon cancer
title_fullStr Development and validation of a five-immune gene prognostic risk model in colon cancer
title_full_unstemmed Development and validation of a five-immune gene prognostic risk model in colon cancer
title_short Development and validation of a five-immune gene prognostic risk model in colon cancer
title_sort development and validation of a five-immune gene prognostic risk model in colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204296/
https://www.ncbi.nlm.nih.gov/pubmed/32375704
http://dx.doi.org/10.1186/s12885-020-06799-0
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