Cargando…

Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study

OBJECTIVE: This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. METHODS: Seventy-five patients with PCOS comorbid psychological distress were randomly allocated i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Qing-jun, Shan, Jing, Xu, Yi-feng, Hu, Yan-yan, Huo, Cui-lan, Song, Jing-yun, Wang, Chao-qun, Zhou, Hui, Yu, Chao-qin, Huang, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204303/ https://www.ncbi.nlm.nih.gov/pubmed/32410849 http://dx.doi.org/10.1155/2020/3050487

Ejemplares similares

Comparison clinical and metabolic effects of metformin and pioglitazone in polycystic ovary syndrome
por: Shahebrahimi, Karoon, et al.
Publicado: (2016)

Evaluating the effect of insulin sensitizers metformin and pioglitazone alone and in combination on women with polycystic ovary syndrome: An RCT
por: Sohrevardi, Seyed Mojtaba, et al.
Publicado: (2016)

Metabolomics Reveals Reduction of Metabolic Oxidation in Women with Polycystic Ovary Syndrome after Pioglitazone-Flutamide-Metformin Polytherapy
por: Vinaixa, Maria, et al.
Publicado: (2011)

Beneficial effects of pioglitazone and metformin in murine model of polycystic ovaries via improvement of chemerin gene up-regulation
por: Kabiri, Nahid, et al.
Publicado: (2014)

Low-Dose Spironolactone-Pioglitazone-Metformin Normalizes Circulating Fetuin-A Concentrations in Adolescent Girls with Polycystic Ovary Syndrome
por: Díaz, Marta, et al.
Publicado: (2018)

Interaction between OCT1 and LPIN1 polymorphisms and response to pioglitazone-metformin tablets in patients with polycystic ovary syndrome
por: Zeng, Haixia, et al.
Publicado: (2023)

Unravelling Polycystic Ovary Syndrome and Its Comorbidities
por: Kim, Kyung-Wook
Publicado: (2021)

Psychological Distress in Women with Polycystic Ovary Syndrome from Imam Khomeini Hospital, Tehran
por: Zangeneh, Farideh Zafari, et al.
Publicado: (2012)

Pioglitazone Enhances Mitochondrial Biogenesis and Ribosomal Protein Biosynthesis in Skeletal Muscle in Polycystic Ovary Syndrome
por: Skov, Vibe, et al.
Publicado: (2008)

Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus
por: Wang, Yao, et al.
Publicado: (2017)

Effects of metformin use in pregnant patients with polycystic ovary syndrome
por: Kumar, Pratap, et al.
Publicado: (2012)

Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility
por: Attia, Ghalia M, et al.
Publicado: (2023)

NLRP3 inflammasome activation is involved in manganese-induced immunotoxicity: Mn activates macrophage NLRP3 inflammasome
por: Ji, Jing, et al.
Publicado: (2021)

Metformin Treatment May Increase Omentin-1 Levels in Women With Polycystic Ovary Syndrome
por: Tan, Bee K., et al.
Publicado: (2010)

The Effectiveness and Safety of Exenatide Versus Metformin in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials
por: Ye, Zheng-Rong, et al.
Publicado: (2023)

The role of NLRP3 inflammasome in psychotropic drug-induced hepatotoxicity
por: Mu, Wenqing, et al.
Publicado: (2022)

NLRP3 inflammasome in endothelial dysfunction
por: Bai, Baochen, et al.
Publicado: (2020)

Effects of metformin on pregnancy outcomes in women with polycystic ovary syndrome: A meta-analysis
por: Zeng, Xian-Ling, et al.
Publicado: (2016)

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
por: Yang, Fan, et al.
Publicado: (2019)

Psychological investigation in patients with polycystic ovary syndrome
por: Bazarganipour, Fatemeh, et al.
Publicado: (2013)

Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation
por: Yan, Jiangbo, et al.
Publicado: (2022)

Comparison of exenatide alone or combined with metformin versus metformin in the treatment of polycystic ovaries: a systematic review and meta-analysis
por: Hu, Yan, et al.
Publicado: (2023)

Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis
por: Zeng, Huamin, et al.
Publicado: (2023)

Short-term combined treatment with exenatide and metformin for overweight/obese women with polycystic ovary syndrome
por: Ma, Rui-Lin, et al.
Publicado: (2021)

Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumor
por: Baba, Tsuyoshi, et al.
Publicado: (2012)

Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice
por: Liu, Jieying, et al.
Publicado: (2023)

The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity
por: Baysak, Erensu, et al.
Publicado: (2023)

Comorbidities in women with polycystic ovary syndrome: a sibling study
por: Boldis, V, et al.
Publicado: (2023)

Therapeutic effects of metformin and clomiphene in combination with lifestyle intervention on infertility in women with obese polycystic ovary syndrome
por: Zhang, Jing, et al.
Publicado: (2017)

Effect of Metformin on Serum Ferritin Level in Women with Polycystic Ovary Syndrome
por: Behradmanesh, S, et al.
Publicado: (2011)

Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome
por: Yang, Young-Mo, et al.
Publicado: (2015)

Clinical outcome of various metformin treatments for women with polycystic ovary syndrome
por: Matsuzaki, Toshiya, et al.
Publicado: (2017)

Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis
por: Peng, Qingjie, et al.
Publicado: (2023)

Impaired Prolactin-Lowering Effects of Metformin in Women with Polycystic Ovary Syndrome
por: Krysiak, Robert, et al.
Publicado: (2023)

A PPARG Splice Variant in Granulosa Cells Is Associated with Polycystic Ovary Syndrome
por: Shi, Chao-Yi, et al.
Publicado: (2022)

Simultaneous Estimation of Metformin and Pioglitazone by Ultraviolet Spectrophotometry
por: Goswami, Laxmi, et al.
Publicado: (2010)

Comparison of the effect between pioglitazone and metformin in treating patients with PCOS:a meta-analysis
por: Xu, Yifeng, et al.
Publicado: (2017)

Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
por: Stener-Victorin, Elisabet, et al.
Publicado: (2019)

NLRP3 Inflammasome and Inflammatory Diseases
por: Wang, Zheng, et al.
Publicado: (2020)

Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome
por: Farimani Sanoee, Marzieh, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6a6kgcke3f7n7anqfk3bjcmp2a