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The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (D...

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Detalles Bibliográficos
Autores principales:	Leitão, Elsa, Di Persio, Sara, Laurentino, Sandra, Wöste, Marius, Dugas, Martin, Kliesch, Sabine, Neuhaus, Nina, Horsthemke, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204326/ https://www.ncbi.nlm.nih.gov/pubmed/32375885 http://dx.doi.org/10.1186/s13148-020-00854-0

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