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Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male

Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The i...

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Autores principales: Menon, Preethi Dileep, Hackman, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204375/
https://www.ncbi.nlm.nih.gov/pubmed/32411490
http://dx.doi.org/10.1155/2020/6247920
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author Menon, Preethi Dileep
Hackman, Sarah
author_facet Menon, Preethi Dileep
Hackman, Sarah
author_sort Menon, Preethi Dileep
collection PubMed
description Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. However, the classic radiologic findings in the later phases of disease show numerous opacities causing a “snowstorm” appearance to the lungs that corresponds with widespread deposition of microliths throughout the lung parenchyma. Although the disease often progresses over a slow time course, there are no effective therapies, and bilateral lung transplantation is recommended when there are increasing oxygen requirements or evidence of pulmonary hypertension.
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spelling pubmed-72043752020-05-14 Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male Menon, Preethi Dileep Hackman, Sarah Case Rep Pathol Case Report Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. However, the classic radiologic findings in the later phases of disease show numerous opacities causing a “snowstorm” appearance to the lungs that corresponds with widespread deposition of microliths throughout the lung parenchyma. Although the disease often progresses over a slow time course, there are no effective therapies, and bilateral lung transplantation is recommended when there are increasing oxygen requirements or evidence of pulmonary hypertension. Hindawi 2020-03-27 /pmc/articles/PMC7204375/ /pubmed/32411490 http://dx.doi.org/10.1155/2020/6247920 Text en Copyright © 2020 Preethi Dileep Menon and Sarah Hackman. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Menon, Preethi Dileep
Hackman, Sarah
Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title_full Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title_fullStr Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title_full_unstemmed Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title_short Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male
title_sort pulmonary alveolar microlithiasis: an isolated case in a hispanic male
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204375/
https://www.ncbi.nlm.nih.gov/pubmed/32411490
http://dx.doi.org/10.1155/2020/6247920
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